Evidence map›Paper›PMID 36322412›Full record

ArticleMolecular biology of the cell2023

A mathematical model of calcium signals around laser-induced epithelial wounds.

Aaron C Stevens, James T O'Connor, Andrew D Pumford, Andrea Page-McCaw, M Shane Hutson

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Physical models of embryonic epithelial healing.PLoS computational biology · 2026
    Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Aaron C StevensDepartment of Physics and Astronomy, Vanderbilt University, Nashville, TN 37232.
James T O'ConnorDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232.
Andrew D PumfordDepartment of Physics and Astronomy, Vanderbilt University, Nashville, TN 37232.
Andrea Page-McCawDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232.
M Shane HutsonDepartment of Physics and Astronomy, Vanderbilt University, Nashville, TN 37232.
Vanderbilt University · US

Funding

Training Program in Stem Cell and Regenerative Developmental BiologyT32HD007502 · NICHD · VANDERBILT UNIVERSITY · PI WRIGHT, CHRISTOPHER V · 1997 to 2022
$5.4M
Cellular Integration of Information in the Detection and Response to Epithelial DamageR01GM130130 · NIGMS · VANDERBILT UNIVERSITY · PI HUTSON, M. SHANE, PAGE-MCCAW, ANDREA · 2018 to 2025
$2.9M
NICHD NIH HHS T32 HD007502NIGMS NIH HHS R01 GM130130
6 · The paper itself

Abstract

Cells around epithelial wounds must first become aware of the wound's presence in order to initiate the wound-healing process. An initial response to an epithelial wound is an increase in cytosolic calcium followed by complex calcium-signaling events. While these calcium signals are driven by both physical and chemical wound responses, cells around the wound will all be equipped with the same cellular components to produce and interact with the calcium signals. Here we have developed a mathematical model in the context of laser ablation of the

Indexed as

CalciumDrosophilaAnimalsCalcium SignalingLasersModels, TheoreticalCalcium

Identifiers

PMID36322412
PMCPMC10208100
OpenAlexW4307966893

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.