ArticleInternational urogynecology journal2023
Pudendal, but not tibial, nerve stimulation modulates vulvar blood perfusion in anesthetized rodents.
Article in International urogynecology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Short-Term Dorsal Genital Nerve Stimulation Increases Subjective Arousal in Women With and Without Spinal Cord Injury: A Preliminary Investigation.Neuromodulation : journal of the International Neuromodulation Society · 2024Trial
- Review
- Neuromodulation for the treatment of sexual dysfunction: an opportunity for the field.Current opinion in biomedical engineering · 2024Article
- Immediate and Long-Term Effects of Tibial Nerve Stimulation on the Sexual Behavior of Female Rats.Neuromodulation : journal of the International Neuromodulation Society · 2024Article
- Updates in pelvic neuromodulation: the role of pelvic neuromodulation in pelvic disorders.Frontiers in urology · 2024Review
- Acute dorsal genital nerve stimulation increases subjective arousal in women with and without spinal cord injury: a preliminary investigation.medRxiv : the preprint server for health sciences · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
introduction and hypothesisPreclinical studies have shown that neuromodulation can increase vaginal blood perfusion, but the effect on vulvar blood perfusion is unknown. We hypothesized that pudendal and tibial nerve stimulation could evoke an increase in vulvar blood perfusion.
methodsWe used female Sprague-Dawley rats for non-survival procedures under urethane anesthesia. We measured perineal blood perfusion in response to 20-minute periods of pudendal and tibial nerve stimulation using laser speckle contrast imaging (LSCI). After a thoracic-level spinalization and a rest period, we repeated each stimulation trial. We calculated average blood perfusion before, during, and after stimulation for three perineal regions (vulva, anus, and inner thigh), for each nerve target and spinal cord condition.
resultsWe observed a significant increase in vulvar, anal, and inner thigh blood perfusion during pudendal nerve stimulation in spinally intact and spinalized rats. Tibial nerve stimulation had no effect on perineal blood perfusion for both spinally intact and spinalized rats.
conclusionsThis is the first study to examine vulvar hemodynamics with LSCI in response to nerve stimulation. This study demonstrates that pudendal nerve stimulation modulates vulvar blood perfusion, indicating the potential of pudendal neuromodulation to improve genital blood flow as a treatment for women with sexual dysfunction. This study provides further support for neuromodulation as a treatment for women with sexual arousal disorders. Studies in unanesthetized animal models of genital arousal disorders are needed to obtain further insights into the mechanisms of neural control over genital hemodynamics.
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