Evidence map›Paper›PMID 36329628›Full record

ArticleCancer medicine2023

Metabolic pathways enriched according to ERG status are associated with biochemical recurrence in Hispanic/Latino patients with prostate cancer.

Natalia L Acosta-Vega, Rodolfo Varela, Jorge Andrés Mesa, Jone Garai, Melody C Baddoo, Alberto Gómez-Gutiérrez, Silvia J Serrano-Gómez, Marcela Nuñez Lemus, Martha Lucía Serrano, Jovanny Zabaleta and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Natalia L Acosta-VegaGrupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología de Colombia, Bogotá, DC, Colombia.ORCID 0000-0002-2467-5446
Rodolfo VarelaDepartamento de Urología, Instituto Nacional de Cancerología de Colombia, Bogotá, DC, Colombia.
Jorge Andrés MesaDepartamento de Patología Oncológica, Instituto Nacional de Cancerología de Colombia, Bogotá, DC, Colombia.
Jone GaraiStanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Melody C BaddooTulane University School of Medicine, New Orleans, Louisiana, USA.
Alberto Gómez-GutiérrezInstituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, DC, Colombia.ORCID 0000-0002-5592-3844
Silvia J Serrano-GómezGrupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología de Colombia, Bogotá, DC, Colombia.ORCID 0000-0002-4144-2556
Marcela Nuñez LemusGrupo de Apoyo y Seguimiento para la Investigación, Instituto Nacional de Cancerología de Colombia, Bogotá, DC, Colombia.
Martha Lucía SerranoGrupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología de Colombia, Bogotá, DC, Colombia.
Jovanny ZabaletaStanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.ORCID 0000-0002-5961-6761
Alba L CombitaGrupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología de Colombia, Bogotá, DC, Colombia.ORCID 0000-0001-6295-7316
María Carolina Sanabria-SalasGrupo de Investigación en Biología del Cáncer, Instituto Nacional de Cancerología de Colombia, Bogotá, DC, Colombia.ORCID 0000-0002-7946-2026
Instituto Nacional de Cancerología · COLouisiana State University Health Sciences Center New Orleans · USPontificia Universidad Javeriana · COUniversidad Nacional de Colombia · COTulane University · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Translational Genomics Core (TGC)P20GM121288 · NIGMS · LSU HEALTH SCIENCES CENTER · PI John T. West · 2017 to 2026
$22.4M
Translational Genomics CoreP30GM114732 · NIGMS · LSU HEALTH SCIENCES CENTER · PI OCHOA, AUGUSTO C. · 2015 to 2019
$5.2M
Pilot ProjectP20CA202922 · NCI · LSU HEALTH SCIENCES CENTER · PI GREGORY, PAULA ELIZABETH, MIELE, LUCIO · 2017 to 2020
$987k
NCI NIH HHS P20 CA202922NIGMS NIH HHS P20 GM121288NIGMS NIH HHS P30 GM114732NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

backgroundThe role of ERG-status molecular subtyping in prognosis of prostate cancer (PCa) is still under debate. In this study, we identified differentially expressed genes (DEGs) according to ERG-status to explore their enriched pathways and implications in prognosis in Hispanic/Latino PCa patients.

methodsRNA from 78 Hispanic PCa tissues from radical prostatectomies (RP) were used for RNA-sequencing. ERG

resultsThe identification of 150 DEGs between ERG

conclusionsERG IMPACT: Our findings suggest the need to dissect the role of diet, metabolism, and lifestyle as risk factors for more aggressive PCa subtypes.

Indexed as

Biomarkers, TumorProstatic NeoplasmsHumansMaleMetabolic Networks and PathwaysNeoplasm Recurrence, LocalPrognosisProstatectomyRNATranscriptional Regulator ERGBiomarkers, TumorERG protein, humanRNATranscriptional Regulator ERGbiochemical recurrencedifferentially expressed genesERG subtypesprostatic neoplasmssignaling pathways

Identifiers

PMID36329628
PMCPMC9972164
OpenAlexW4308179009

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.