ArticleCell2022
Architecture of the outbred brown fat proteome defines regulators of metabolic physiology.
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Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
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Who cites it
28 citing papers in PubMed, 35 citations in OpenAlex.
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- The proteomic landscape and temporal dynamics of human and mouse gastruloid development.Nature cell biology · 2026Article
- Gabpα-Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Fifteen years of the Diversity Outbred mouse model: a review.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Review
- Latest Advances in Obesity Treatment by Regulating Adipocyte Thermogenesis.PPAR research · 2026Review
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- Phenolic compounds and epigenetic mechanisms regulating gene expression: effects on human health.Journal of physiology and biochemistry · 2025Review
- Sex-specific systemic metabolic predictors of resistance to calorie restriction-induced weight loss in obese diversity outbred mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- A pathway that controls conversion of the amino acid cysteine into a cholesterol regulator.Nature · 2025Article
- 2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction.Nature metabolism · 2025Article
- Genome-wide identification of the H3K27ac signals reveals key thermogenic cis-regulatory elements of brown adipose tissues in Oryctolagus cuniculus.BMC genomics · 2025Article
- Technologies for Decoding Cancer Metabolism with Spatial Resolution.Cold Spring Harbor perspectives in medicine · 2025Review
- Cold exposure stimulates cross-tissue metabolic rewiring to fuel glucose-dependent thermogenesis in brown adipose tissue.Science advances · 2025Article
- Ablation of FAM210A in Brown Adipocytes of Mice Exacerbates High-Fat Diet-Induced Metabolic Dysfunction.Diabetes · 2025Article
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- LETM-domain containing 1 (LETMD1) protects against obesity via enhancing UCP1-independent energy expenditure in human beige adipocytes.Theranostics · 2025Article
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- Unlocking metabolic insights with mouse genetic diversity.The EMBO journal · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors at 12 institutions in 2 countries.
Haopeng XiaoDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: haopeng_xiao@dfci.harvard.edu.
Luiz H M BoziDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Yizhi SunDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Christopher L RileyDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Vivek M PhilipThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Mandy ChenThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Jiaming LiDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Tian ZhangDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Evanna L MillsDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Margo P EmontDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Wenfei SunDepartment of Bioengineering, Stanford University, CA 94305, USA; Department of Molecular and Cellular Physiology, Stanford University, CA 94305, USA.
Anita ReddyDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Ryan GarrityDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Jiani LongCollege of Computing, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Tobias BecherLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY 10065, USA.
Laura Potano VitasDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Dina Laznik-BogoslavskiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Martha OrdonezDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Xinyue LiuDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Xiong ChenDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Yun WangDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong 510275, China.
Weihai LiuDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Nhien TranDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Yitong LiuDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Yang ZhangSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
Aaron M CypessDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Andrew P WhiteDepartment of Orthopedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Yuchen HeDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Rebecca DengDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Heiko SchöderDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Mark P JedrychowskiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Alexander S BanksDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Yu-Hua TsengSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
Paul CohenLaboratory of Molecular Metabolism, The Rockefeller University, New York, NY 10065, USA.
Linus T TsaiDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Evan D RosenDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Samuel KleinCenter for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USA.
Maria ChondronikolaDepartment of Nutrition, UC Davis, Davis, CA 95616, USA.
Fiona E McAllisterCalico Life Sciences LLC, South San Francisco, CA 94080, USA.
Nick Van BruggenCalico Life Sciences LLC, South San Francisco, CA 94080, USA.
Edward L HuttlinDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Bruce M SpiegelmanDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Gary A ChurchillThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Edward T ChouchaniDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: edwardt_chouchani@dfci.harvard.edu.
Harvard University · USBeth Israel Deaconess Medical Center · USDana-Farber Cancer Institute · USJackson Laboratory · USJoslin Diabetes Center · USMemorial Sloan Kettering Cancer Center · USRockefeller University · USGeorgia Institute of Technology · USNational Institutes of Health · USStanford University · USUniversity of California, Davis · USWashington University in St. Louis · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MSPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5MTransgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2000 to 2019
$31.4MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI HU, FRANK B · 1992 to 2021
$25.0MInvestigating Human Adipocyte HeterogeneityRC2DK116691 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Orr Ashenberg, Noel P Burtt · 2018 to 2026
$17.8MUCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6MINTEGRATED ENDOCRINE &METABOLIC RESEARCH TRAININGT32DK007516 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BARBARA B. KAHN · 1986 to 2026
$6.8MSystems Genetic Analysis of Multi-parent CrossesR01GM070683 · NIGMS · JACKSON LABORATORY · PI BROMAN, KARL W, CHURCHILL, GARY A · 2004 to 2022
$6.8MSystematic Exploration of the Human Interactome IVU24HG006673 · NHGRI · HARVARD MEDICAL SCHOOL · PI GYGI, STEVEN P, HARPER, JEFFREY W · 2018 to 2025
$6.0MSystematic Exploration of the Human InteractomeU41HG006673 · NHGRI · HARVARD MEDICAL SCHOOL · PI HUTTLIN, EDWARD LEO · 2012 to 2017
$5.5MP&F programP30DK135043 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Dennis Brown · 2023 to 2026
$5.4MNCI NIH HHS K99 CA273170NCI NIH HHS P30 CA008748NHGRI NIH HHS U24 HG006673NHGRI NIH HHS U41 HG006673NIA NIH HHS K99 AG073461NIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30 DK046200NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30 DK057521NIDDK NIH HHS P30 DK098722NIDDK NIH HHS P30 DK135043NIDDK NIH HHS R01 DK087092NIDDK NIH HHS R01 DK102173NIDDK NIH HHS R01 DK102898NIDDK NIH HHS R01 DK123095NIDDK NIH HHS RC2 DK116691NIDDK NIH HHS T32 DK007516NIGMS NIH HHS R01 GM070683
Abstract
Brown adipose tissue (BAT) regulates metabolic physiology. However, nearly all mechanistic studies of BAT protein function occur in a single inbred mouse strain, which has limited the understanding of generalizable mechanisms of BAT regulation over physiology. Here, we perform deep quantitative proteomics of BAT across a cohort of 163 genetically defined diversity outbred mice, a model that parallels the genetic and phenotypic variation found in humans. We leverage this diversity to define the functional architecture of the outbred BAT proteome, comprising 10,479 proteins. We assign co-operative functions to 2,578 proteins, enabling systematic discovery of regulators of BAT. We also identify 638 proteins that correlate with protection from, or sensitivity to, at least one parameter of metabolic disease. We use these findings to uncover SFXN5, LETMD1, and ATP1A2 as modulators of BAT thermogenesis or adiposity, and provide OPABAT as a resource for understanding the conserved mechanisms of BAT regulation over metabolic physiology.
Indexed as
Adipose Tissue, BrownProteomeAdiposityAnimalsHumansMiceMice, Inbred C57BLObesityProto-Oncogene ProteinsThermogenesisLETMD1 protein, humanProteomeProto-Oncogene Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.