Evidence map›Paper›PMID 36337926›Full record

ArticleJACC. Basic to translational science2022

Plasminogen Activator Inhibitor-1-Positive Platelet-Derived Extracellular Vesicles Predicts MACE and the Proinflammatory SMC Phenotype.

Richard G Jung, Anne-Claire Duchez, Trevor Simard, Shan Dhaliwal, Taylor Gillmore, Pietro Di Santo, Alisha Labinaz, F Daniel Ramirez, Adil Rasheed, Sabrina Robichaud and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Dipyridamole and vascular healing following stent implantation.Frontiers in cardiovascular medicine · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Richard G JungCAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Anne-Claire DuchezDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Trevor SimardCAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Shan DhaliwalCAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Taylor GillmoreFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Pietro Di SantoCAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Alisha LabinazCAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
F Daniel RamirezCAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Adil RasheedDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Sabrina RobichaudDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Mireille OuimetDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Spencer ShortFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Cole CliffordFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Fengxia XiaoKidney Research Centre, Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Marie LordkipanidzéFaculté de Pharmacie, Université de Montréal, Montréal, Québec, Canada.
Dylan BurgerKidney Research Centre, Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Suresh GaddeDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Katey J RaynerDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Benjamin HibbertCAPITAL Research Group, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with established coronary artery disease remain at elevated risk of major adverse cardiac events. The goal of this study was to evaluate the utility of plasminogen activator inhibitor-1-positive platelet-derived extracellular vesicles as a biomarker for major adverse cardiac events and to explore potential underlying mechanisms. Our study suggests these extracellular vesicles as a potential biomarker to identify and a therapeutic target to ameliorate neointimal formation of high-risk patients.

Indexed as

biomarkersCAD, coronary artery diseaseCMFDA, 5-chloromethylfluorescein diacetateDAPT, dual antiplatelet therapyDMSO, dimethyl sulfoxideEV, extracellular vesicleextracellular vesiclesin-stent restenosisLRP1, low-density lipoprotein–related receptor-1MACE, major adverse cardiac eventsPAI-1+ PEV, plasminogen activator inhibitor-1–positive platelet-derived extracellular vesiclePAI, plasminogen activator inhibitorPCI, percutaneous coronary interventionpercutaneous coronary interventionPEV, platelet-derived extracellular vesicleplasminogen activator inhibitor-1stent thrombosisT-TAS, Total Thrombus-formation Analysis SystemVSMC, vascular smooth muscle cells

Identifiers

PMID36337926
PMCPMC9626902

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.