Evidence map›Paper›PMID 36337946›Full record

ArticleRSC advances2022

Negatively-charged supported lipid bilayers regulate neuronal adhesion and outgrowth.

Chiara Ausilio, Claudia Lubrano, Anna Mariano, Francesca Santoro

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. How Neuromorphic Microstructures Control In Vitro Early-Stage Neuronal Outgrowth.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Concealing Organic Neuromorphic Devices with Neuronal-Inspired Supported Lipid Bilayers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Chiara AusilioTissue Electronics, Istituto Italiano di Tecnologia 80125 Napoli Italy.
Claudia LubranoTissue Electronics, Istituto Italiano di Tecnologia 80125 Napoli Italy.
Anna MarianoTissue Electronics, Istituto Italiano di Tecnologia 80125 Napoli Italy.
Francesca SantoroTissue Electronics, Istituto Italiano di Tecnologia 80125 Napoli Italy.ORCID https://orcid.org/0000-0001-7323-9504
Forschungszentrum Jülich · DEItalian Institute of Technology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the main challenges in neuroelectronics is the implementation of electronic platforms able to secure a tight coupling with neuronal cells and achieve an optimal signal to noise ratio during stimulation/recording of electrophysiological activity. In this context, supported lipid bilayers (SLBs), recapitulating the structure and the dynamicity of the biological plasma membrane, offer a promising biomimetic approach to trick cells to recognize a device as part of their native environment, tightening the cell-chip coupling. Among possible functionalization strategies used to improve cell adhesion on SLBs, the modification of the bilayer surface charge has been exploited to enhance the electrostatic interaction between the artificial membrane and its biological counterpart. In this work, several SLBs with different lipidic composition were synthesized and interfaced with primary neurons. Starting from a neuron-inspired biomembrane, the negative charges were increased through the addition of 1,2-dipalmitoyl-

Identifiers

PMID36337946
PMCPMC9590245
OpenAlexW4308555687

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.