Evidence map›Paper›PMID 36338342›Full record

ArticleOxidative medicine and cellular longevity2022

Administration of N-Acetylcysteine to Regress the Fibrogenic and Proinflammatory Effects of Oxidative Stress in Hypertrophic Ligamentum Flavum Cells.

Yu-Chia Hsu, Hao-Chun Chuang, Kun-Ling Tsai, Ting-Yuan Tu, Yan-Jye Shyong, Cheng-Hsiang Kuo, Yuan-Fu Liu, Shu-Shien Shih, Cheng-Li Lin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Inflammatory Biomarkers in Smokers: Implications for Ligamentum Flavum Hypertrophy.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yu-Chia HsuDepartment of Orthopaedic Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0001-5666-9238
Hao-Chun ChuangDepartment of Orthopaedic Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0001-9408-0651
Kun-Ling TsaiDepartment of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0002-3814-1453
Ting-Yuan TuDepartment of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0002-1816-4615
Yan-Jye ShyongDepartment of Clinical Pharmacy and Pharmaceutical Sciences, National Cheng Kung University, Tainan 70101, Taiwan.ORCID https://orcid.org/0000-0002-9480-918X
Cheng-Hsiang KuoDepartment of Biochemistry and Molecular Biology, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0002-4885-9020
Yuan-Fu LiuDepartment of Orthopaedic Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0002-7363-4851
Shu-Shien ShihDepartment of Orthopaedic Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0003-4793-6861
Cheng-Li LinDepartment of Orthopaedic Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID https://orcid.org/0000-0002-7315-7709
National Cheng Kung University Hospital · TWNational Cheng Kung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ligamentum flavum hypertrophy (LFH) is a major cause of lumbar spinal stenosis (LSS). In hypertrophic ligamentum flavum (LF) cells, oxidative stress activates intracellular signaling and induces the expression of inflammatory and fibrotic markers. This study explored whether healthy and hypertrophic LF cells respond differently to oxidative stress, via examining the levels of phosphorylated p38 (p-p38), inducible nitric oxide synthase (iNOS), and

Indexed as

Ligamentum FlavumAcetylcysteineCollagen Type IHumansHydrogen PeroxideHypertrophyOxidative StressTransforming Growth Factor betaVimentinAcetylcysteineCollagen Type IHydrogen PeroxideTransforming Growth Factor betaVimentin

Identifiers

PMID36338342
PMCPMC9629932
OpenAlexW4307446604

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.