Identifying lncRNA-disease association based on GAT multiple-operator aggregation and inductive matrix completion.

Computable models as a fundamental candidate for traditional biological experiments have been applied in inferring lncRNA-disease association (LDA) for many years, without time-consuming and laborious limitations. However, sparsity inherently existing in known heterogeneous bio-data is an obstacle to computable models to improve prediction accuracy further. Therefore, a new computational model composed of multiple mechanisms for lncRNA-disease association (MM-LDA) prediction was proposed, based on the fusion of the graph attention network (GAT) and inductive matrix completion (IMC). MM-LDA has two key steps to improve prediction accuracy: first, a multiple-operator aggregation was designed in the n-heads attention mechanism of the GAT. With this step, features of lncRNA nodes and disease nodes were enhanced. Second, IMC was introduced into the enhanced node features obtained in the first step, and then the LDA network was reconstructed to solve the cold start problem when data deficiency of the entire row or column happened in a known association matrix. Our MM-LDA achieved the following progress: first, using the Adam optimizer that adaptively adjusted the model learning rate could increase the convergent speed and not fall into local optima as well. Second, more excellent predictive ability was achieved against other similar models (with an AUC value of 0.9395 and an AUPR value of 0.8057 obtained from 5-fold cross-validation). Third, a 6.45% lower time cost was consumed against the advanced model GAMCLDA. In short, our MM-LDA achieved a more comprehensive prediction performance in terms of prediction accuracy and time cost.