Evidence map›Paper›PMID 36339035›Full record

ArticleFrontiers in chemistry2022

Detection of abemaciclib, an anti-breast cancer agent, using a new electrochemical DNA biosensor.

Zimeng Lei, Merim Alwan, Hassan Thoulfikar A Alamir, Hussein Humedy Chlib Alkaaby, Sinan Subhi Farhan, Sura A Awadh, Usama S Altimari, Hawra'a Fadhel Abbas Al-Baghdady, Athmar Ali Kadhim, Maytham T Qasim and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 31 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 3 countries.

Zimeng LeiSchool of International Education, Beijing University of Chemical Technology, Beijing, China.
Merim AlwanMedical Lab. Techniques Department, College of Medical Technology, Al-Farahidi University, Baghdad, Iraq.
Hassan Thoulfikar A AlamirFaculty of Pharmacy Department of Pharmaceutics, University of Al-Ameed, Karbala, Iraq.
Hussein Humedy Chlib AlkaabyAl-Manara College for Medical Sciences, Maysan, Iraq.
Sinan Subhi FarhanThe University of Mashreq, Baghdad, Iraq.
Sura A AwadhDepartment of Anesthesia, Al-mustaqbal University, Babylon, Iraq.
Usama S AltimariAl-Nisour University College, Baghdad, Iraq.
Hawra'a Fadhel Abbas Al-BaghdadyHawra'a Fadhel Abbas AL-Baghdady, College of Dentistry, The Islamic University, Najaf, Iraq.
Athmar Ali KadhimMedical Laboratories Teachniques, Hilla University College Babylon, Babylon, Iraq.
Maytham T QasimDepartment of Anesthesia, College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq.
Ali Hussein AdhabDepartment of Medical Laboratory Technics, Al-Zahrawi University College, Karbala, Iraq.
Abuzar NekueiIslamic Azad University of South Tehran Branch, Tehran, Iran.
University of Karbala · IQAl-Ayen UniversityAl-Farahidi UniversityAl-Nisour University College · IQBeijing University of Chemical Technology · CNIraqi University · IQIslamic Azad University South Tehran Branch · IRUniversity of Babylon · IQ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Detection of DNA molecules and possible chemotherapy-induced changes in its structure has been the goal of researchers using rapid, sensitive and inexpensive approaches. Therefore, the aim of this study was to fabricate a new electrochemical DNA biosensor using pencil graphite electrodes modified with polypyrrole/Ce doped hexagonal nickel oxide nanodisks or PP/Ce-doped H-NiO-ND composites for determination of Abemaciclib (AMC) and ds-DNA molecules. The DNA biosensor was prepared by immobilizing ds-DNA on the surface of PP/Ce-doped H-NiO-ND/PGE. Differential pulse voltammetry (DPV) was used to electrochemically detect AMC. The results elucidate the extremely high sensitivity of the ds-DNA/PP/Ce-doped H-NiO-ND/PGE biosensor to AMC, with a narrow detection limit of 2.7 nM and a lengthy linear range of 0.01-600.0 μM. The admirable performance of as-fabricated biosensor could be related to the active reaction sites and the unique electrochemical response related to the nanocomposites by enhancing ds-DNA stabilization and accelerating electron transfer on the surface of electrode.

Indexed as

abemaciclibanti-breast cancer agentDNA biosensormodified electrodevoltammetry

Identifiers

PMID36339035
PMCPMC9635563
OpenAlexW4306952273

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.