ArticleScientific reports2022
Condensed tannins act as anthelmintics by increasing the rigidity of the nematode cuticle.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Organ-Specific Distribution of Bioactive Compounds inAntioxidants (Basel, Switzerland) · 2026Article
- Combined ethanolic extracts ofVeterinary world · 2026Article
- The Role of Natural Anthelmintics in Small Ruminant Health: A Global Narrative Review.Animals : an open access journal from MDPI · 2026Review
- Future Perspectives: Mass Spectrometry for Spatial Localisation of Anti-Angiogenic Oil Palm Compounds.International journal of molecular sciences · 2026Review
- Targeted supplementation with bioactive plants sustainably improves goat health and decreases antiparasitic drug use on smallholder farms.Scientific reports · 2026Article
- The use of pumpkin seeds as an alternative anthelmintic to reduce parasite burden in naturally infected lambs.Translational animal science · 2026Article
- Induction of proline-rich proteins in response to tannin treatment in Caenorhabditis elegans.Scientific reports · 2025Article
- Anthelmintic effects of Areca catechu L. (Arecaceae) and Piper betle L. (Piperaceae) combination on adult Haemonchus spp.: a scanning electron microscopy study.BMC veterinary research · 2025Article
- Evaluation of lyophilizedVeterinary world · 2025Article
- Article
- Anthelminthic Activity ofScientifica · 2025Article
- Phytochemical analysis and anthelmintic activity of Combretum mucronatum leaf extract against infective larvae of soil-transmitted helminths including ruminant gastrointestinal nematodes.Parasites & vectors · 2024Article
- Influence of fecal fermentation on the anthelmintic activity of proanthocyanidins and ellagitannins against human intestinal nematodes andFrontiers in pharmacology · 2024Article
- Anthelmintic Activity of Ethanolic and Aqueous Extracts ofJournal of tropical medicine · 2024Article
- Aqueous Extracts of Organic Mulch Materials Have Nematicide and Repellent Effect onJournal of nematology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tannins and tanniferous plant extracts have been discussed as sustainable means for helminth control in the past two decades in response to a dramatic increase of resistances towards standard anthelmintics. While their bioactivities have been broadly investigated in vitro and in vivo, less is known about their mode of action in nematodes, apart from their protein binding properties. In the current study we therefore investigated the impact of a phytochemically well characterized plant extract from Combretum mucronatum, known to contain procyanidins as the active compounds, on the model organism Caenorhabditis elegans. By different microscopic techniques, the cuticle was identified as the main binding site for tannins, whereas underlying tissues did not seem to be affected. In addition to disruptions of the cuticle structure, molting defects occurred at all larval stages. Finally, an increased rigidity of the nematodes' cuticle due to binding of tannins was confirmed by force spectroscopic measurements. This could be a key finding to explain several anthelmintic activities reported for tannins, especially impairment of molting or exsheathment as well as locomotion.
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