Evidence map›Paper›PMID 36345253›Full record

ArticleClinical endocrinology2023

The postprandial secretion of peptide YY

Anna M Kowalka, Kleopatra Alexiadou, Joyceline Cuenco, Rosemary E Clarke, James Minnion, Emma L Williams, Paul Bech, Sanjay Purkayastha, Ahmed R Ahmed, Zoltan Takats and 7 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01945840 (Do Gut Hormones Mediate the Beneficial Effects of Roux-en-Y Bypass?), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01945840 narecruitingnot on this map

Do Gut Hormones Mediate the Beneficial Effects of Roux-en-Y Bypass?

TypeinterventionalSponsorImperial College LondonRan2013 to 2028Enrolled190ConditionsObesity, Type 2 DiabetesArmsRoux en Y Gastric Bypass Surgery, Gut hormone infusion, Placebo infusion, Very low calorie diet
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. The postprandial secretion of peptide YYClinical endocrinology · 2023
    Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Anna M KowalkaSection of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0002-6251-7369
Kleopatra AlexiadouSection of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0001-8412-0592
Joyceline CuencoSection of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Rosemary E ClarkeBlood Sciences Department, Raigmore Hospital, Inverness, UK.
James MinnionSection of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Emma L WilliamsDepartment of Clinical Biochemistry, North West London Pathology, Charing Cross Hospital, London, UK.
Paul BechSection of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Sanjay PurkayasthaDepartment of Surgery and Cancer, Imperial College Healthcare NHS Trust, London, UK.
Ahmed R AhmedDepartment of Surgery and Cancer, Imperial College Healthcare NHS Trust, London, UK.
Zoltan TakatsSection of Bioanalytical Chemistry, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Harry J WhitwellSection of Bioanalytical Chemistry, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Maria Gomez RomeroSection of Bioanalytical Chemistry, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Stephen R BloomSection of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Stephane CamuzeauxSection of Bioanalytical Chemistry, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0002-4614-4662
Matthew R LewisSection of Bioanalytical Chemistry, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0001-5760-5359
Bernard KhooEndocrinology, Division of Medicine, University College London, London, UK.ORCID 0000-0002-4223-9736
Tricia M-M TanSection of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.ORCID 0000-0001-5873-3432
Imperial College London · GBImperial College Healthcare NHS Trust · GBCharing Cross Hospital · GBRaigmore Hospital · GBUniversity College London · GB

Funding

Department of Health 13/121/07Department of Health NC_PC_12025Medical Research Council MR/K02115X/1
6 · The paper itself

Abstract

objectivesPeptide tyrosine tyrosine (PYY) exists as two species, PYY DESIGN AND SUBJECTS: Observational study in 10 healthy nonobese volunteers and 30 participants with obesity who underwent RYGB (n = 24) or SG (n = 6) at the Imperial Weight Centre [NCT01945840]. Participants were studied using a standardized mixed meal test (MMT) before and 1 year after surgery. The outcome measures were PYY

resultsPresurgery, the fasting and postprandial levels of PYY

conclusionsThere appears to be no difference in PYY secretion between nonobese and obese volunteers at baseline. At 1 year after surgery, RYGB, but not SG, is associated with increased postprandial secretion of PYY

Indexed as

Gastric BypassBlood GlucoseChromatography, LiquidGastrectomyHumansObesityPeptide YYTandem Mass SpectrometryTyrosineBlood GlucosePeptide YYTyrosinegastric bypassLC-MS/MSobesityPYYtype 2 diabetes

Identifiers

PMID36345253
PMCPMC10952770
OpenAlexW4308425024

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.