Evidence map›Paper›PMID 36348115›Full record

ArticleResults and problems in cell differentiation2022

Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle.

Mohammed El Dika, Andrew J Fritz, Rabail H Toor, Princess D Rodriguez, Stephen J Foley, Rahim Ullah, Daijing Nie, Bodhisattwa Banerjee, Dorcas Lohese, Kirsten M Tracy and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Results and problems in cell differentiation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Macrophage Cell Cycle.Results and problems in cell differentiation · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Mohammed El Dika *Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.ORCID https://orcid.org/0000-0002-0999-1061
Andrew J Fritz *Department of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
Rabail H ToorDepartment of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
Princess D RodriguezDepartment of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, USA.
Stephen J FoleyDepartment of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
Rahim UllahDepartment of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
Daijing NieDepartment of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
Bodhisattwa BanerjeeDepartment of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
Dorcas LoheseDepartment of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
Kirsten M TracyDepartment of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
Karen C GlassDepartment of Pharmacology, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
Seth FrietzeCollege of Nursing and Health Sciences, University of Vermont, Burlington, VT, USA.
Prachi N GhuleDepartment of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
Jessica L HeathDepartment of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
Anthony N ImbalzanoDepartment of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, MA, USA.
Andre van WijnenDepartment of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
Jonathan GordonDepartment of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
Jane B LianDepartment of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
Janet L SteinDepartment of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA.
Gary S SteinDepartment of Biochemistry, Larner College of Medicine, UVM Cancer Center, University of Vermont, Burlington, VT, USA. gary.stein@med.uvm.edu.

Funding

Understanding Factors Influencing COVID-19 Testing and Vaccination in Immigrant Low-income and Homeless Populations and Testing Targeted InterventionsU54GM115516 · NIGMS · MAINEHEALTH · PI Susan L SANTANGELO · 2017 to 2026
$51.6M
Project 3: MANCR Mediates Epigenetic Mechanisms for Survival of Advanced Breast CancerP01CA240685 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI STEIN, JANET L · 2021 to 2025
$8.7M
CONTROL OF OSTEOBLAST PROLIFERATION AND DIFFERENTIATIONR01AR039588 · NIAMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIAN, JANE B., STEIN, GARY S. · 1990 to 2019
$8.0M
Chromatin Organization Regulates OsteogenesisR01DE029311 · NIDCR · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI LIAN, JANE B., STEIN, GARY S. · 2020 to 2024
$2.5M
Deciphering the molecular mechanisms of histone code recognition by ATAD2/BR01GM129338 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI FRIETZE, SETH E, GLASS, KAREN CHAMPAGNE · 2018 to 2022
$2.1M
Understanding Ikaros molecular functions for targeted therapies of pre-B ALLR01CA230618 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRIETZE, SETH E, SCHJERVEN, HILDE · 2018 to 2022
$1.8M
Supplement to AWD32581 - Fritz fellowship F32CA220935F32CA220935 · NCI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI FRITZ, ANDREW J · 2018 to 2021
$216k
NCI NIH HHS F32 CA220935NCI NIH HHS P01 CA240685NCI NIH HHS R01 CA230618NIAMS NIH HHS R01 AR039588NIDCR NIH HHS R01 DE029311NIGMS NIH HHS R01 GM129338NIGMS NIH HHS U54 GM115516
6 · The paper itself

Abstract

The cell cycle is governed by stringent epigenetic mechanisms that, in response to intrinsic and extrinsic regulatory cues, support fidelity of DNA replication and cell division. We will focus on (1) the complex and interdependent processes that are obligatory for control of proliferation and compromised in cancer, (2) epigenetic and topological domains that are associated with distinct phases of the cell cycle that may be altered in cancer initiation and progression, and (3) the requirement for mitotic bookmarking to maintain intranuclear localization of transcriptional regulatory machinery to reinforce cell identity throughout the cell cycle to prevent malignant transformation.

Indexed as

Epigenesis, GeneticNeoplasmsCell CycleCell DivisionChromatinGene Expression RegulationHumansChromatinCell cycle controlChromatinEpigenetic controlHistonesMitotic gene bookmarkingNuclear structureNucleosomesTranscriptionTumor suppression

Identifiers

PMID36348115
PMCPMC9703624

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.