Evidence map›Paper›PMID 36350201›Full record

ArticlePediatric obesity2022

Association of total and pancreatic serum amylase enzymatic activity with insulin resistance and the glucose and insulin responses to oral starch test in Mexican children.

Daniel Locia-Morales, Miguel Vázquez-Moreno, Roxana González-Dzib, Carmen Domínguez-Hernández, Aleyda Pérez-Herrera, Roberto J Robles-Ramírez, Alberto Rocha-Cruz, David Meyre, Eugenia Flores-Alfaro, Miguel Cruz

Open access · hybridAbstract read
In one paragraph

Article in Pediatric obesity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Daniel Locia-MoralesUnidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Miguel Vázquez-MorenoUnidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social, Mexico City, Mexico.ORCID 0000-0002-9170-0488
Roxana González-DzibInstituto Mexicano del Seguro Social, Jefatura de los Servicios de Prestaciones Médicas, Coordinación Auxiliar Médica de Investigación en Salud, Campeche, Mexico.
Carmen Domínguez-HernándezInstituto Mexicano del Seguro Social, Jefatura de los Servicios de Prestaciones Médicas, Coordinación Auxiliar Médica de Investigación en Salud, Campeche, Mexico.
Aleyda Pérez-HerreraConsejo Nacional de Ciencia y Tecnología, Instituto Politécnico Nacional-Centro Interdisciplinario de Investigación para el Desarrollo Integral-Regional Unidad Oaxaca, Oaxaca City, Mexico.
Roberto J Robles-RamírezLaboratorio de Patología Clínica, División de Auxiliares de Diagnóstico y Tratamiento, Hospital de Pediatría, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Alberto Rocha-CruzLaboratorio de Patología Clínica, División de Auxiliares de Diagnóstico y Tratamiento, Hospital de Pediatría, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social, Mexico City, Mexico.
David MeyreDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-4850-7444
Eugenia Flores-AlfaroLaboratorio de Investigación en Epidemiología Clínica y Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Mexico.
Miguel CruzUnidad de Investigación Médica en Bioquímica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social, Mexico City, Mexico.ORCID 0000-0001-9985-6172
Mexican Social Security Institute · MXInserm · FRInstituto Tecnológico de Oaxaca · MXUniversidad Autónoma de Guerrero · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesLittle is known about the effect of serum amylase enzymatic activity on glucose metabolism. We investigated the association of serum amylase enzymatic activity with fasting plasma glucose, insulin resistance (IR), and the plasma glucose and insulin response to an oral starch test (OST) in Mexican children.

methodsAnthropometric data, glucose and insulin levels, and the serum enzymatic activity of total (AMYt), salivary (AMY1), and pancreatic (AMY2) amylase were analysed in 764 children (N

resultsA positive association between serum enzymatic activity of AMY2 and IR was observed in children with obesity (p = 0.018). Children with normal weight had lower plasma glucose and insulin response to OST than children with obesity (P

conclusionOur results suggest that AMY2 is positively associated with IR. A high level of AMYt is related to lower glucose and insulin responses to OST in Mexican children, regardless of their weight status.

Indexed as

Insulin ResistanceSalivary alpha-AmylasesAmylasesBlood GlucoseChildGlucoseHumansInsulinObesityStarchAmylasesBlood GlucoseGlucoseInsulinSalivary alpha-AmylasesStarchinsulin resistanceMexican childrenoral starch testserum amylase

Identifiers

PMID36350201
PMCPMC9787783
OpenAlexW4292413699

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.