Evidence map›Paper›PMID 36350672›Full record

ArticleNucleic acids research2023

InterPro in 2022.

Typhaine Paysan-Lafosse, Matthias Blum, Sara Chuguransky, Tiago Grego, Beatriz Lázaro Pinto, Gustavo A Salazar, Maxwell L Bileschi, Peer Bork, Alan Bridge, Lucy Colwell and 16 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,427 papers.

0numbers the graph read from it
0cells of the map it votes in
1,427citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,427 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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  10. Leveraging latent space models for enzyme discovery and sampling.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  12. Genome analysis of the glycosphingolipid-producing green alga tetraselmis sp. NKG400013.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026
    Article
  13. Review
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  15. Review
  16. Investigating enzyme function by geometric matching of catalytic motifs.Protein science : a publication of the Protein Society · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Article

1,367 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Typhaine Paysan-LafosseEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.ORCID 0000-0001-5663-0894
Matthias BlumEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.ORCID 0000-0001-5773-4724
Sara ChuguranskyEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.ORCID 0000-0002-0520-0736
Tiago GregoEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.ORCID 0000-0002-7946-7062
Beatriz Lázaro PintoEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.ORCID 0000-0001-6837-2941
Gustavo A SalazarEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.ORCID 0000-0001-9208-4966
Maxwell L BileschiGoogle Research, Brain team, Cambridge, MA, USA.ORCID 0000-0001-6771-0590
Peer BorkEuropean Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany.ORCID 0000-0002-2627-833X
Alan BridgeSwiss-Prot Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, CH-1211, Geneva 4, Switzerland.ORCID 0000-0003-2148-9135
Lucy ColwellGoogle Research, Brain team, Cambridge, MA, USA.ORCID 0000-0003-3148-0337
Julian GoughMedical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Ave, Trumpington, Cambridge CB2 0QH, UK.ORCID 0000-0002-1965-4982
Daniel H HaftNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA.ORCID 0000-0001-8101-4938
Ivica LetunićBiobyte Solutions GmbH, Bothestr 142, 69126 Heidelberg, Germany.ORCID 0000-0003-3560-4288
Aron Marchler-BauerNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA.ORCID 0000-0003-1516-0712
Huaiyu MiDivision of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0001-8721-202X
Darren A NataleProtein Information Resource, Georgetown University Medical Center, Washington, DC 20007, USA.ORCID 0000-0001-5809-9523
Christine A OrengoDepartment of Structural and Molecular Biology, University College London, Gower St, Bloomsbury, London WC1E 6BT, UK.ORCID 0000-0002-7141-8936
Arun P PanduranganMedical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Ave, Trumpington, Cambridge CB2 0QH, UK.ORCID 0000-0001-7168-7143
Catherine RivoireSwiss-Prot Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, CH-1211, Geneva 4, Switzerland.ORCID 0000-0002-5979-8382
Christian J A SigristSwiss-Prot Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, CH-1211, Geneva 4, Switzerland.ORCID 0000-0002-4348-0070
Ian SillitoeDepartment of Structural and Molecular Biology, University College London, Gower St, Bloomsbury, London WC1E 6BT, UK.ORCID 0000-0003-1091-9144
Narmada ThankiNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA.ORCID 0000-0003-1181-2509
Paul D ThomasDivision of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.ORCID 0000-0002-9074-3507
Silvio C E TosattoDepartment of Biomedical Sciences, University of Padua, via U. Bassi 58/b, 35131 Padua, Italy.ORCID 0000-0003-4525-7793
Cathy H WuProtein Information Resource, Georgetown University Medical Center, Washington, DC 20007, USA.ORCID 0000-0001-6379-8601
Alex BatemanEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.ORCID 0000-0002-6982-4660

Funding

National Biomedical Information ServicesZIHLM200888 · NLM · NATIONAL LIBRARY OF MEDICINE · PI PALTOO, DINA · 2009 to 2025
$5200.7M
Resource ProjectU41HG002273 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMAS, PAUL D. · 2012 to 2021
$34.7M
Gene Ontology Consortium and KnowledgebaseU24HG012212 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHRISTOPHER J MUNGALL, PAUL Warren STERNBERG · 2022 to 2026
$11.6M
Protein Knowledge Networks and Semantic Computing for Disease DiscoveryR35GM141873 · NIGMS · UNIVERSITY OF DELAWARE · PI WU, CATHY H. · 2021 to 2025
$2.2M
Medical Research Council MC_UP_1201/14NHGRI NIH HHS U24 HG012212NHGRI NIH HHS U41 HG002273NIGMS NIH HHS R35 GM141873Wellcome Trust
6 · The paper itself

Abstract

The InterPro database (https://www.ebi.ac.uk/interpro/) provides an integrative classification of protein sequences into families, and identifies functionally important domains and conserved sites. Here, we report recent developments with InterPro (version 90.0) and its associated software, including updates to data content and to the website. These developments extend and enrich the information provided by InterPro, and provide a more user friendly access to the data. Additionally, we have worked on adding Pfam website features to the InterPro website, as the Pfam website will be retired in late 2022. We also show that InterPro's sequence coverage has kept pace with the growth of UniProtKB. Moreover, we report the development of a card game as a method of engaging the non-scientific community. Finally, we discuss the benefits and challenges brought by the use of artificial intelligence for protein structure prediction.

Indexed as

Databases, ProteinAmino Acid SequenceArtificial IntelligenceHumansInternetProteinsSoftwareProteins

Identifiers

PMID36350672
PMCPMC9825450

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.