Evidence map›Paper›PMID 36351545›Full record

SynthesisJournal of sport and health science2023

Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials.

Antonio García-Hermoso, Robinson Ramírez-Vélez, Javier Díez, Arantxa González, Mikel Izquierdo

Open access · diamondAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of sport and health science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 5 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 5 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  6. Trial
  7. Article
  8. Review
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  13. Mechanistic insights into the liver-brain axis during chronic liver disease.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  14. Article
  15. Observational
  16. Review
  17. Review
  18. Review
  19. Exercise, Exerkines, and Sarcopenia.Diabetes & metabolism journal · 2026
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Antonio García-HermosoNavarrabiomed, Public University of Navarra (UPNA), Health Research Institute of Navarra (IdiSNA), University Hospital of Navarra, Pamplona 310008, Spain; CIBER of Frailty and Healthy Aging (CIBERFES), Carlos III Institute of Health, Madrid 28029, Spain. Electronic address: antonio.garciah@unavarra.es.
Robinson Ramírez-VélezNavarrabiomed, Public University of Navarra (UPNA), Health Research Institute of Navarra (IdiSNA), University Hospital of Navarra, Pamplona 310008, Spain; CIBER of Frailty and Healthy Aging (CIBERFES), Carlos III Institute of Health, Madrid 28029, Spain; Institute for Health Research of Navarra (IDISNA), Pamplona 31008, Spain.
Javier DíezInstitute for Health Research of Navarra (IDISNA), Pamplona 31008, Spain; Program of Cardiovascular Diseases, Center for Applied Medical Research, University of Navarra, Pamplona 31008, Spain; Centre for Biomedical Research in Cardiovascular Disease Network, Carlos III Institute of Health, Madrid 28029, Spain; Departments of Nephrology and Cardiology, University of Navarra Clinic, Pamplona 31008, Spain.
Arantxa GonzálezInstitute for Health Research of Navarra (IDISNA), Pamplona 31008, Spain; Program of Cardiovascular Diseases, Center for Applied Medical Research, University of Navarra, Pamplona 31008, Spain; Centre for Biomedical Research in Cardiovascular Disease Network, Carlos III Institute of Health, Madrid 28029, Spain.
Mikel IzquierdoNavarrabiomed, Public University of Navarra (UPNA), Health Research Institute of Navarra (IdiSNA), University Hospital of Navarra, Pamplona 310008, Spain; CIBER of Frailty and Healthy Aging (CIBERFES), Carlos III Institute of Health, Madrid 28029, Spain; Institute for Health Research of Navarra (IDISNA), Pamplona 31008, Spain.
Instituto de Salud Carlos III · ESUniversidad de Navarra · ESNavarrabiomed · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study investigates the effects of exercise training on exerkines in patients with type 2 diabetes mellitus to determine the optimal exercise prescription.

methodsA systematic search for relevant studies was performed in 3 databases. Randomized controlled trials investigating the effects of exercise training on at least one of the following exerkines were included: adiponectin, apelin, brain-derived neurotrophic factor, fetuin-A, fibroblast growth factor-21, follistatin, ghrelin, interleukin (IL)-6, IL-8, IL-10, IL-15, IL-18, leptin, myostatin, omentin, resistin, retinol-binding protein 4, tumor necrosis factor-α, and visfatin.

resultsForty randomized controlled trials were selected for data extraction (n = 2160). Exercise training induces changes in adiponectin, fetuin-A, fibroblast growth factor-21, IL-6, IL-10, leptin, resistin, and tumor necrosis factor-α levels but has no significant effects on apelin, IL-18, and ghrelin compared to controls. Physical exercise training favored large and positive changes in pooled exerkines (i.e., an overall effect size calculated from several exerkines) (Hedge's g = 1.02, 95% confidence interval (95%CI): 0.76-1.28), which in turn were related to changes in glycated hemoglobin (mean difference (MD) = -0.81%, 95%CI: -0.95% to -0.67%), fasting glucose (MD = -23.43 mg/dL, 95%CI: -30.07 mg/dL to -16.80 mg/dL), waist circumference (MD = -3.04 cm, 95%CI: -4.02 cm to -2.07 cm), and body mass (MD = -1.93 kg, 95%CI: -2.00 kg to -1.86 kg). Slightly stronger effects were observed with aerobic, resistance, or high-intensity interval protocols at moderate- to vigorous-intensity and with programs longer than 24 weeks that comprise at least 3 sessions per week and more than 60 min per session.

conclusionExercise training represents an anti-inflammatory therapy and metabolism-improving strategy with minimal side effects for patients with type 2 diabetes mellitus.

Indexed as

Diabetes Mellitus, Type 2Adiponectinalpha-2-HS-GlycoproteinApelinExerciseFibroblast Growth FactorsGhrelinHumansInterleukin-10Interleukin-18LeptinRandomized Controlled Trials as TopicResistinTumor Necrosis Factor-alphaAdiponectinalpha-2-HS-GlycoproteinApelinFibroblast Growth FactorsGhrelinInterleukin-10Interleukin-18LeptinResistinTumor Necrosis Factor-alphaAdipokinesExercise trainingHepatokinesMyokines

Identifiers

PMID36351545
PMCPMC10105032
OpenAlexW4308455066

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.