Evidence map›Paper›PMID 36353774›Full record

ArticleImmunology and cell biology2023

High activation levels maintained in receptor-binding domain-specific memory B cells in people with severe coronavirus disease 2019.

Money Gupta, Harikrishnan Balachandran, Raymond H Y Louie, Hui Li, David Agapiou, Elizabeth Keoshkerian, Daniel Christ, William Rawlinson, Michael M Mina, Jeffrey J Post and 12 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology and cell biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Overview of Oxidative Stress in Systemic Lupus Erythematosus.Antioxidants (Basel, Switzerland) · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 1 country.

Money GuptaFaculty of Medicine, School of Medical Sciences, University of New South Wales Australia, Sydney, NSW, Australia.
Harikrishnan BalachandranFaculty of Medicine, School of Medical Sciences, University of New South Wales Australia, Sydney, NSW, Australia.
Raymond H Y LouieFaculty of Medicine, School of Medical Sciences, University of New South Wales Australia, Sydney, NSW, Australia.ORCID 0000-0002-9384-2447
Hui LiThe Kirby Institute, University of New South Wales, Australia, Sydney, NSW, Australia.
David AgapiouThe Kirby Institute, University of New South Wales, Australia, Sydney, NSW, Australia.
Elizabeth KeoshkerianThe Kirby Institute, University of New South Wales, Australia, Sydney, NSW, Australia.
Daniel ChristAntibody Therapeutics Lab, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.
William RawlinsonFaculty of Medicine, School of Medical Sciences, University of New South Wales Australia, Sydney, NSW, Australia.
Michael M MinaNorthern Beaches Hospital, Frenchs Forest, NSW, Australia.
Jeffrey J PostPrince of Wales Clinical School, University of New South Wales, Australia, Sydney, NSW, Australia.
Bernard HudsonInfectious diseases, Royal North Shore Hospital, Sydney, NSW, Australia.
Nicky GilroyInfectious Diseases, Westmead Hospital, Sydney, NSW, Australia.
Pamela KonecnySt George and Sutherland Clinical School, University of New South Wales, Sydney, Sydney, NSW, Australia.
Adam W BartlettFaculty of Medicine, School of Medical Sciences, University of New South Wales Australia, Sydney, NSW, Australia.
Sarah C SassonThe Kirby Institute, University of New South Wales, Australia, Sydney, NSW, Australia.
Golo AhlenstielBlacktown Mount Druitt Hospital, Blacktown, NSW, Australia.
Dominic DwyerInfectious Diseases, Westmead Hospital, Sydney, NSW, Australia.
Andrew R LloydThe Kirby Institute, University of New South Wales, Australia, Sydney, NSW, Australia.
Marianne MartinelloThe Kirby Institute, University of New South Wales, Australia, Sydney, NSW, Australia.
Fabio LucianiFaculty of Medicine, School of Medical Sciences, University of New South Wales Australia, Sydney, NSW, Australia.
Rowena A BullFaculty of Medicine, School of Medical Sciences, University of New South Wales Australia, Sydney, NSW, Australia.ORCID 0000-0002-9844-3744
COSIN study group
The University of Sydney · AUUNSW Sydney · AUBlacktown & Mount Druitt Hospital · AUWestmead Hospital · AUGarvan Institute of Medical Research · AURoyal North Shore Hospital · AUSutherland Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The long-term health consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are still being understood. The molecular and phenotypic properties of SARS-CoV-2 antigen-specific T cells suggest a dysfunctional profile that persists in convalescence in those who were severely ill. By contrast, the antigen-specific memory B-cell (MBC) population has not yet been analyzed to the same degree, but phenotypic analysis suggests differences following recovery from mild or severe coronavirus disease 2019 (COVID-19). Here, we performed single-cell molecular analysis of the SARS-CoV-2 receptor-binding domain (RBD)-specific MBC population in three patients after severe COVID-19 and four patients after mild/moderate COVID-19. We analyzed the transcriptomic and B-cell receptor repertoire profiles at ~2 months and ~4 months after symptom onset. Transcriptomic analysis revealed a higher level of tumor necrosis factor-alpha (TNF-α) signaling via nuclear factor-kappa B in the severe group, involving CD80, FOS, CD83 and TNFAIP3 genes that was maintained over time. We demonstrated the presence of two distinct activated MBCs subsets based on expression of CD80

Indexed as

COVID-19Antibodies, ViralConvalescenceHumansMemory B CellsSARS-CoV-2Antibodies, ViralCD11cCD95memory B cellsRBDSARS-CoV-2

Identifiers

PMID36353774
PMCPMC9878167
OpenAlexW4308682910

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.