Evidence map›Paper›PMID 36354074›Full record

ReviewJournal of molecular biology2022

Binding and Functional Folding (BFF): A Physiological Framework for Studying Biomolecular Interactions and Allostery.

Brianna D Young, Mary E Cook, Brianna K Costabile, Riya Samanta, Xinhao Zhuang, Spiridon E Sevdalis, Kristen M Varney, Filippo Mancia, Silvina Matysiak, Eaton Lattman and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Biomolecular NMR assignments · 2025
    Article
  2. Article
  3. Article
  4. Transcriptome Analysis of thePlants (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Brianna D YoungThe Center for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Mary E CookThe Center for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Brianna K CostabileDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA.
Riya SamantaBiophysics Graduate Program, University of Maryland, College Park, MD 20742, USA; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Xinhao ZhuangThe Center for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Spiridon E SevdalisThe Center for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Kristen M VarneyThe Center for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Filippo ManciaDepartment of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA.
Silvina MatysiakBiophysics Graduate Program, University of Maryland, College Park, MD 20742, USA; Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Eaton LattmanThe Center for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Physics, Arizona State University, Tempe, AZ 85287, USA.
David J WeberThe Center for Biomolecular Therapeutics (CBT), Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA; The Institute of Bioscience and Biotechnology Research (IBBR), Rockville, MD 20850, USA. Electronic address: dweber@som.umaryland.edu.

Funding

950 MHz NMR Spectrometer with Cryogenic ProbeS10RR029601 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI WEBER, DAVID JOSEPH · 2010 to 2010
$8.0M
Signal Propagation in Protein Allostery: Mechanism and EvolutionR01GM129327 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI WEBER, DAVID JOSEPH · 2019 to 2022
$1.3M
Structure-based targeting of the C. difficile toxin (CDT) from hypervirulent bacterial strainsR56AI152397 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DES GEORGES, AMEDEE, WEBER, DAVID JOSEPH · 2021 to 2021
$522k
600 MHz NMR Spectrometer ConsoleS10RR023447 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI WEBER, DAVID JOSEPH · 2007 to 2007
$362k
NCRR NIH HHS S10 RR023447NCRR NIH HHS S10 RR029601NIAID NIH HHS R56 AI152397NIGMS NIH HHS R01 GM129327
6 · The paper itself

Abstract

EF-hand Ca

Indexed as

CalmodulinEF Hand MotifsS100 ProteinsAllosteric RegulationHumansProtein BindingProtein ConformationProtein FoldingCalmodulinS100 Proteinsallosterybinding and functional foldingCa(2+)-signalingcalmodulinS100 proteins

Identifiers

PMID36354074
PMCPMC10871162

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.