Evidence map›Paper›PMID 36354440›Full record

ArticleBiosensors2022

Prostate-Specific Antigen Monitoring Using Nano Zinc(II) Metal-Organic Framework-Based Optical Biosensor.

Said M El-Sheikh, Sheta M Sheta, Salem R Salem, Mohkles M Abd-Elzaher, Amal S Basaleh, Ammar A Labib

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Said M El-SheikhDepartment of Nanomaterials and Nanotechnology, Central Metallurgical R & D Institute, Cairo 11421, Egypt.ORCID 0000-0002-2570-8326
Sheta M ShetaDepartment of Inorganic Chemistry, National Research Centre, Cairo 12622, Egypt.ORCID 0000-0002-8069-7105
Salem R SalemDepartment of Biochemistry, Egypt Centre for Research and Regenerative Medicine, Cairo 11887, Egypt.
Mohkles M Abd-ElzaherDepartment of Inorganic Chemistry, National Research Centre, Cairo 12622, Egypt.ORCID 0000-0002-5434-9668
Amal S BasalehDepartment of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
Ammar A LabibDepartment of Inorganic Chemistry, National Research Centre, Cairo 12622, Egypt.ORCID 0000-0002-1564-3477
National Research Centre · EGCentral Metallurgical Research and Development Institute · EGEgypt Center for Research and Regenerative Medicine · EGKing Abdulaziz University · SA

Funding

Science and Technology Development Fund 37068
6 · The paper itself

Abstract

backgroundThe prostate-specific antigen (PSA) is an important cancer biomarker that is commonly utilized in the diagnosis of prostate cancer. The development of a PSA determination technique that is rapid, simple, and inexpensive, in addition to highly accurate, sensitive, and selective, remains a formidable obstacle.

methodsIn this study, we developed a practical biosensor based on Zn(II) metal-organic framework nanoparticles (Zn-MOFs-NPs). Many spectroscopic and microanalytical tools are used to determine the structure, morphology, and physicochemical properties of the prepared MOF.

resultsAccording to the results, Zn-MOFs-NPs are sensitive to PSA, selective to an extremely greater extent, and stable in terms of chemical composition. Furthermore, the Zn-MOFs-NPs did not exhibit any interferences from other common analytes that might cause interference. The detection limit for PSA was calculated and was 0.145 fg/mL throughout a wide linear concentration range (0.1 fg/mL-20 pg/mL).

conclusionsZn-MOFs-NPs were successfully used as a growing biosensor for the monitoring and measurement of PSA in biological real samples.

Indexed as

Biosensing TechniquesMetal NanoparticlesMetal-Organic FrameworksProstatic NeoplasmsElectrochemical TechniquesHumansLimit of DetectionMaleProstate-Specific AntigenZincMetal-Organic FrameworksProstate-Specific AntigenZincbiosensormetal–organic framework based on zinc(ii)nanoparticlesphotoluminescenceprostate antigen

Identifiers

PMID36354440
PMCPMC9688191
OpenAlexW4307635347

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.