Evidence map›Paper›PMID 36354737›Full record

ArticleeLife2022

Systematic analysis of membrane contact sites in

Inês Gomes Castro, Shawn P Shortill, Samantha Katarzyna Dziurdzik, Angela Cadou, Suriakarthiga Ganesan, Rosario Valenti, Yotam David, Michael Davey, Carsten Mattes, Ffion B Thomas and 10 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Heterogeneity, dynamics and organelle interactions of lipid droplets.Nature reviews. Molecular cell biology · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Imaging interorganelle contacts at a glance.Journal of cell science · 2024
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. The peroxisome: an update on mysteries 3.0.Histochemistry and cell biology · 2024
    Review
  19. Review
  20. Imaging and proteomics toolkits for studying organelle contact sites.Frontiers in cell and developmental biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 5 countries.

Inês Gomes Castro *Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0003-4669-985X
Shawn P Shortill *Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.ORCID 0000-0001-8742-7442
Samantha Katarzyna Dziurdzik *Centre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.ORCID 0000-0002-3553-1595
Angela Cadou *Laboratory for Molecular Cell Biology, University College London, London, United Kingdom.
Suriakarthiga GanesanDepartment of Biological Sciences, University of Calgary, Calgary, Canada.ORCID 0000-0001-7430-7740
Rosario ValentiDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0002-6093-1873
Yotam DavidDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0003-4992-7045
Michael DaveyCentre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.ORCID 0000-0002-1172-5934
Carsten MattesMedical Biochemistry and Molecular Biology, PZMS, Medical Faculty, Saarland University, Homburg, Germany.
Ffion B ThomasLaboratory for Molecular Cell Biology, University College London, London, United Kingdom.ORCID 0000-0002-1899-1397
Reut Ester AvrahamDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Hadar MeyerDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-5725-0447
Amir FadelDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Emma J FenechDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0003-4414-3233
Robert ErnstMedical Biochemistry and Molecular Biology, PZMS, Medical Faculty, Saarland University, Homburg, Germany.ORCID 0000-0002-0283-3490
Vanina ZarembergDepartment of Biological Sciences, University of Calgary, Calgary, Canada.ORCID 0000-0001-7009-2172
Tim P LevineUCL Institute of Ophthalmology, University College London, London, United Kingdom.ORCID 0000-0002-7231-0775
Christopher StefanLaboratory for Molecular Cell Biology, University College London, London, United Kingdom.ORCID 0000-0002-4118-5721
Elizabeth ConibearCentre for Molecular Medicine and Therapeutics, British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, Canada.ORCID 0000-0001-5129-0499
Maya SchuldinerDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0001-9947-115X
Weizmann Institute of Science · ILUniversity of British Columbia · CAMRC Laboratory for Molecular Cell Biology · GBSaarland University · DEUniversity of Calgary · CAInstitute of Ophthalmology · MX

Funding

Biotechnology and Biological Sciences Research Council BB/M011801/1CIHR 148756Medical Research Council MC_UU_00012/6
6 · The paper itself

Abstract

Actively maintained close appositions between organelle membranes, also known as contact sites, enable the efficient transfer of biomolecules between cellular compartments. Several such sites have been described as well as their tethering machineries. Despite these advances we are still far from a comprehensive understanding of the function and regulation of most contact sites. To systematically characterize contact site proteomes, we established a high-throughput screening approach in

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAutophagy-Related ProteinsErgosterolLipid DropletsLipidsATG2 protein, S cerevisiaeAutophagy-Related ProteinsErgosterolLipidsSaccharomyces cerevisiae ProteinsVPS13 protein, S cerevisiaecell biologycontact siteslec1lipid dropletsS. cerevisiaevps13 familyYPR097W

Identifiers

PMID36354737
PMCPMC9648973
OpenAlexW4308864026

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.