Evidence map›Paper›PMID 36357486›Full record

ArticleCommunications biology2022

NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance.

Rose Hodgson, Xijin Xu, Consuelo Anzilotti, Mukta Deobagkar-Lele, Tanya L Crockford, Jessica D Kepple, Eleanor Cawthorne, Aneesha Bhandari, Alberto Cebrian-Serrano, Martin J Wilcock and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Rose HodgsonMRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-9157-045X
Xijin XuMRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Consuelo AnzilottiMRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-4528-0651
Mukta Deobagkar-LeleMRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-8543-6801
Tanya L CrockfordMRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Jessica D KeppleWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Eleanor CawthorneMRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Aneesha BhandariMRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Alberto Cebrian-SerranoWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-4737-0215
Martin J WilcockMRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Benjamin DaviesWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Richard J CornallMRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK. richard.cornall@ndm.ox.ac.uk.ORCID 0000-0002-6213-3269
Katherine R BullMRC Human Immunology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Katherine.bull@ndm.ox.ac.uk.ORCID 0000-0003-0656-0917
Centre for Human Genetics · GBUniversity of Oxford · GB

Funding

Medical Research Council MC_UU_00008/6Medical Research Council MR/R007748/1
6 · The paper itself

Abstract

Peripheral tolerance prevents the initiation of damaging immune responses by autoreactive lymphocytes. While tolerogenic mechanisms are tightly regulated by antigen-dependent and independent signals, downstream pathways are incompletely understood. N-myc downstream-regulated gene 1 (NDRG1), an anti-cancer therapeutic target, has previously been implicated as a CD4

Indexed as

Charcot-Marie-Tooth DiseaseRefsum DiseaseAnimalsImmune ToleranceLymphocyte ActivationMiceT-Lymphocytes

Identifiers

PMID36357486
PMCPMC9649591
OpenAlexW4309074960

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.