ReviewAntioxidants (Basel, Switzerland)2022
Oxidative Stress and Inflammatory Biomarkers for Populations with Occupational Exposure to Nanomaterials: A Systematic Review and Meta-Analysis.
Review in Antioxidants (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Anti-Inflammatory and Analgesic Properties ofBiomedicines · 2026Review
- Article
- Toxicity Evaluation of Nano-Sized Particles by Analysis of mtDNA Content and Expression Levels of Genes Required for mtDNA Maintenance: A Meta-Analysis of Pre-Clinical Studies.Antioxidants (Basel, Switzerland) · 2026Review
- Article
- Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Occupational zirconium and co-metal exposure - cobalt, nickel, and arsenic: an integrated air and biomonitoring assessment in Taiwanese industry.Journal of occupational medicine and toxicology (London, England) · 2025Article
- 3D printing: Balancing innovation for sustainability with emerging environmental and health risks.iScience · 2025Review
- Are there Risks from Nanocomposite Restoration Grinding for Dentists?International dental journal · 2025Article
- Worse pulmonary function in association with cumulative exposure to nanomaterials. Hints of a mediation effect via pulmonary inflammation.Particle and fibre toxicology · 2024Article
- Occupational Exposure to Metal-Based Nanomaterials: A Possible Relationship between Chemical Composition and Oxidative Stress Biomarkers.Antioxidants (Basel, Switzerland) · 2024Article
- The utilization of nanotechnology in the female reproductive system and related disorders.Heliyon · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to nanomaterials (NMs) is suggested to have the potential to cause harmful health effects. Activations of oxidative stress and inflammation are assumed as main contributors to NM-induced toxicity. Thus, oxidative stress- and inflammation-related indicators may serve as biomarkers for occupational risk assessment. However, the correlation between NM exposure and these biomarkers remains controversial. This study aimed to perform a meta-analysis to systematically investigate the alterations of various biomarkers after NM exposure. Twenty-eight studies were found eligible by searching PubMed, EMBASE and Cochrane Library databases. The pooled results showed NM exposure was significantly associated with increases in the levels of malonaldehyde (MDA) [standardized mean difference (SMD) = 2.18; 95% confidence interval (CI), 1.50-2.87], 4-hydroxy-2-nonhenal (HNE) (SMD = 2.05; 95% CI, 1.13-2.96), aldehydes C6-12 (SMD = 3.45; 95% CI, 2.80-4.10), 8-hydroxyguanine (8-OHG) (SMD = 2.98; 95% CI, 2.22-3.74), 5-hydroxymethyl uracil (5-OHMeU) (SMD = 1.90; 95% CI, 1.23-2.58), o-tyrosine (o-Tyr) (SMD = 1.81; 95% CI, 1.22-2.41), 3-nitrotyrosine (3-NOTyr) (SMD = 2.63; 95% CI, 1.74-3.52), interleukin (IL)-1β (SMD = 1.76; 95% CI, 0.87-2.66), tumor necrosis factor (TNF)-α (SMD = 1.52; 95% CI, 1.03-2.01), myeloperoxidase (MPO) (SMD = 0.25; 95% CI, 0.16-0.34) and fibrinogen (SMD = 0.11; 95% CI, 0.02-0.21), and decreases in the levels of glutathione peroxidase (GPx) (SMD = -0.31; 95% CI, -0.52--0.11) and IL-6 soluble receptor (IL-6sR) (SMD = -0.18; 95% CI, -0.28--0.09). Subgroup analysis indicated oxidative stress biomarkers (MDA, HNE, aldehydes C6-12, 8-OHG, 5-OHMeU, o-Tyr, 3-NOTyr and GPx) in exhaled breath condensate (EBC) and blood samples were strongly changed by NM exposure; inflammatory biomarkers (IL-1β, TNF-α, MPO, fibrinogen and IL-6sR) were all significant in EBC, blood, sputum and nasal lavage samples. In conclusion, our findings suggest that these oxidative stress and inflammatory indicators may be promising biomarkers for the biological monitoring of occupationally NM-exposed workers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.