Evidence map›Paper›PMID 36358652›Full record

ArticleCancers2022

Trabectedin for Patients with Advanced Soft Tissue Sarcoma: A Non-Interventional, Prospective, Multicenter, Phase IV Trial.

Viktor Grünwald, Daniel Pink, Gerlinde Egerer, Enrico Schalk, Marinela Augustin, Christoph K W Deinzer, Viola Kob, Dietmar Reichert, Maxim Kebenko, Stephan Brandl and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 17 institutions in 2 countries.

Viktor GrünwaldInnere Klinik (Tumorforschung) und Klinik für Urologie, Universitätsklinikum Essen, 45147 Essen, Germany.ORCID 0000-0003-2083-7687
Daniel PinkHelios Klinikum Bad-Saarow, Klinik für Onkologie und Palliativmedizin, Sarkomzentrum Berlin-Brandenburg, 15526 Bad Saarow, Germany.ORCID 0000-0001-7243-7373
Gerlinde EgererKlinik für Hämatologie, Onkologie, Rheumatologie, Universitätsklinikum Heidelberg, 69120 Heidelberg, Germany.
Enrico SchalkMedical Center, Otto-von-Guericke University Magdeburg, 39106 Magdeburg, Germany.ORCID 0000-0003-1892-5098
Marinela AugustinKlinikum Nürnberg Nord, Schwerpunkt Onkologie/Hämatologie, Klinik für Innere Medizin 5, Paracelsus Medizinische Privatuniversität, 90419 Nürnberg, Germany.
Christoph K W DeinzerHämatologie und Internistische Onkologie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, 97078 Würzburg, Germany.
Viola KobSchwerpunktpraxis Hämatologie/Onkologie Volksdorf, MVZ für Immunologie Lokstedt GmbH, 20251 Hamburg, Germany.
Dietmar ReichertGemeinschaftspraxis für Hämatologie und Onkologie, Kuhlenstraße 53d, 26655 Westerstede, Germany.
Maxim KebenkoKlinik für Hämatologie und Onkologie, Universitätsklinikum Schleswig-Holstein, 23538 Lübeck, Germany.
Stephan BrandlÜberörtliche Gemeinschaftspraxis Bergedorf, 21029 Hamburg, Germany.
Dennis HahnKlinik für Hämatologie, Onkologie und Palliativmedizin, Klinikum Stuttgart, 70174 Stuttgart, Germany.
Lars H LindnerMedizinische Klinik und Poliklinik III, LMU Klinikum-Campus Großhadern, 81377 München, Germany.ORCID 0000-0003-3708-8264
Mathias HoiczykMedizinischen Klinik II, Marien-Hospital Wesel gGmbH, 46483 Wesel, Germany.
Uta RingsdorfLahn-Dill-Kliniken GmbH, Gynäkologischen Tumorzentrums Lahn-Dill, 35578 Wetzlar, Germany.
Lars C HankerKlinik für Frauenheilkunde und Geburtshilfe (Gynäkologie), Universitätsklinikum Schleswig-Holstein, 23538 Lübeck, Germany.
Dirk HempelOnkologisches Zentrum, 86609 Donauwörth, Germany.
Beatriz De RivasMedical Affairs, PharmaMar, S.A., Colmenar Viejo, 28770 Madrid, Spain.ORCID 0000-0002-8620-7234
Tobias WismannPraxis für Onkologie und Urologie, 26389 Wilhelmshaven, Germany.
Philipp IvanyiHämostaseologie, Onkologie und Stammzelltransplantation, Klinik für Hämatologie, Claudia von Schilling Zentrum Comprehensive Cancer Center, Medizinische Hochschule Hannover, 30625 Hannover, Germany.
Praxis für Hämatologie und Onkologie · DEDillinger Hütte (Germany) · DEHeidelberg University · DEKlinik Donaustauf · DEKlinik für Frauenheilkunde · DEKlinikum Stuttgart · DEKlinik und Poliklinik für Urologie · DELMU Klinikum · DEMarien Hospital Wesel · DEMedizinische Hochschule Hannover · DENuremberg Hospital · DEOtto-von-Guericke-Universität Magdeburg · DEPharmaMar (Spain) · ESPraxis für Humangenetik · DEUniversitätsklinikum Würzburg · DEUniversitätsmedizin Greifswald · DEUniversity Hospital Schleswig-Holstein · DE

Funding

PharmaMar (Spain) 0000
6 · The paper itself

Abstract

This non-interventional, prospective phase IV trial evaluated trabectedin in patients with soft tissue sarcoma (STS) in real-life clinical practice across Germany. The primary endpoints were progression-free survival (PFS) rates at 3 and 6 months, as defined by investigators. Overall, 128 patients from 19 German sites were evaluated for efficacy and 130 for safety. Median age was 58.5 years (range: 23-84) and leiomyosarcoma was the most frequent histotype (

Indexed as

non-interventionalprospectivesarcomaSTStrabectedin

Identifiers

PMID36358652
PMCPMC9653615
OpenAlexW4307372421

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.