Evidence map›Paper›PMID 36358748›Full record

ArticleCancers2022

Body Mass Index and Overall Survival of Patients with Newly Diagnosed Multiple Myeloma.

Bei Wang, Benjamin A Derman, Spencer S Langerman, Julie Johnson, Wei Zhang, Andrzej Jakubowiak, Brian C-H Chiu

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Multiple myeloma.Nature reviews. Disease primers · 2024
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Bei WangDepartment of Public Health Sciences, University of Chicago, Chicago, IL 60637, USA.
Benjamin A DermanSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-4070-1819
Spencer S LangermanDepartment of Public Health Sciences, University of Chicago, Chicago, IL 60637, USA.
Julie JohnsonCenter for Research Informatics, University of Chicago, Chicago, IL 60615, USA.
Wei ZhangDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0003-0875-263X
Andrzej JakubowiakSection of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.
Brian C-H ChiuDepartment of Public Health Sciences, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-8979-7244
Chicago Department of Public Health · USUniversity of Chicago · USNorthwestern University · US

Funding

Epigenomic markers of circulating cell-free DNA and treatment outcome in multiple myelomaR01CA223662 · NCI · UNIVERSITY OF CHICAGO · PI CHIU, BRIAN C-H, ZHANG, WEI · 2018 to 2022
$3.2M
A highly sensitive linear amplification based DNA methylation profiling technique for clinical cancer researchR33CA269100 · NCI · UNIVERSITY OF CHICAGO · PI CHIU, BRIAN C-H, ZHANG, WEI · 2022 to 2024
$1.2M
NCI NIH HHS R01 CA223662NCI NIH HHS R33 CA269100NIH HHS R01CA223662 (B.C. and W.Z.) and R33CA269100 (B.C. and W.Z.)
6 · The paper itself

Abstract

Obesity is associated with survival in several solid tumors and non-Hodgkin lymphoma, but its impact on multiple myeloma (MM) survival is unclear. We examined the associations between body mass index (BMI) at different periods of life up to the time of diagnosis and overall survival (OS) among 563 patients newly diagnosed with MM in 2010-2019. BMI at diagnosis was calculated using measured height and weight from electronic medical records (EMR). BMIs at age 20, maximum during adulthood, and 5 years before diagnosis were calculated using self-reported weights and measured height from EMR. Over a median follow-up of 49.3 months, 191 (33.93%) deaths were identified. We used multivariable Cox proportional-hazards models to examine the associations between BMIs and OS. Height as well as BMI before and at diagnosis was not associated with OS, but there is a U-shape association between weight and OS. Higher BMIs at diagnosis were associated with better OS among females (HR = 0.39 [0.22-0.71]), irrespective of race. In conclusion, our results suggest that BMI at different periods of life up to the time of diagnosis may not be associated with OS in MM, except that a higher BMI at diagnosis was associated with superior OS for females.

Indexed as

body mass indexmultiple myelomaobesityoverall survival

Identifiers

PMID36358748
PMCPMC9657446
OpenAlexW4307944139

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.