Evidence map›Paper›PMID 36358934›Full record

ArticleBiomolecules2022

Submilligram Level of Beetle Antifreeze Proteins Minimize Cold-Induced Cell Swelling and Promote Cell Survival.

Keiko Omori, Ignacio Gonzalez, Cindy Nguyen, Shanti N Raminani, Victor M Deleon, Pedro Meza, Jose Zamalloa, Rachel G Perez, Nelson Gonzalez, Hirotake Komatsu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Keiko OmoriDepartment of Translational Research and Cellular Therapeutics, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA.
Ignacio GonzalezDepartment of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA 90032, USA.
Cindy NguyenDepartment of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA 90032, USA.
Shanti N RaminaniDepartment of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA 90032, USA.ORCID 0000-0003-1305-1045
Victor M DeleonDepartment of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA 90032, USA.
Pedro MezaDepartment of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA 90032, USA.
Jose ZamalloaDepartment of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA 90032, USA.
Rachel G PerezDepartment of Translational Research and Cellular Therapeutics, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA.
Nelson GonzalezDepartment of Translational Research and Cellular Therapeutics, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA.
Hirotake KomatsuDepartment of Translational Research and Cellular Therapeutics, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA.ORCID 0000-0003-0876-4809
Ismail H Al-AbdullahDepartment of Translational Research and Cellular Therapeutics, Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA 91010, USA.
Xin WenDepartment of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA 90032, USA.ORCID 0000-0002-2465-7870
California State University Los Angeles · USCity of Hope · US

Funding

IDENTIFICATION AND MOLECULAR BASIS FOR EFFICIENT ANTIFREEZE PROTIEN ENHANCERSSC3GM086249 · NIGMS · CALIFORNIA STATE UNIVERSITY LOS ANGELES · PI WEN, XIN · 2009 to 2023
$1.7M
CSULA-COH Collaborative to Study Cancer DisparitiesP20CA118783 · NCI · CALIFORNIA STATE UNIVERSITY LOS ANGELES · PI MOMAND, JAMIL A · 2006 to 2009
$907k
NCI NIH HHS P20 CA118783NIGMS NIH HHS SC3 GM086249NIH HHS SC3GM086249
6 · The paper itself

Abstract

Hypothermic (cold) preservation is a limiting factor for successful cell and tissue transplantation where cell swelling (edema) usually develops, impairing cell function. University of Wisconsin (UW) solution, a standard cold preservation solution, contains effective components to suppress hypothermia-induced cell swelling. Antifreeze proteins (AFPs) found in many cold-adapted organisms can prevent cold injury of the organisms. Here, the effects of a beetle AFP from

Indexed as

ColeopteraAdenosineAllopurinolalpha-FetoproteinsAnimalsAntifreeze ProteinsCell SurvivalEdemaGlutathioneInsulinOrgan Preservation SolutionsRaffinoseRatsAdenosineAllopurinolalpha-FetoproteinsAntifreeze ProteinsGlutathioneInsulinOrgan Preservation SolutionsRaffinoseUniversity of Wisconsin-lactobionate solutionantifreeze proteincell swellingpost-hypothermic preservation survival

Identifiers

PMID36358934
PMCPMC9687565
OpenAlexW4307943820

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.