Evidence map›Paper›PMID 36360874›Full record

ReviewInternational journal of environmental research and public health2022

Sodium Nitrite Intoxication and Death: Summarizing Evidence to Facilitate Diagnosis.

Martina Padovano, Mariarosaria Aromatario, Stefano D'Errico, Monica Concato, Federico Manetti, Maria Chiara David, Matteo Scopetti, Paola Frati, Vittorio Fineschi

Open access · goldAbstract readReview
In one paragraph

Review in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Suicide by sodium nitrite ingestion: a systematic review.Forensic science, medicine, and pathology · 2026
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Martina PadovanoDepartment of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-2452-7926
Mariarosaria AromatarioUnit of Risk Management, Quality, and Accreditation, Sant'Andrea University Hospital, 00189 Rome, Italy.
Stefano D'ErricoDepartment of Medicine, Surgery and Health, University of Trieste, 34137 Trieste, Italy.ORCID 0000-0003-3689-0001
Monica ConcatoDepartment of Medicine, Surgery and Health, University of Trieste, 34137 Trieste, Italy.
Federico ManettiDepartment of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Maria Chiara DavidDepartment of Public Security, Health Central Directorate, Research Center and Forensic Toxicology Laboratory, Ministry of the Interior, 00184 Rome, Italy.ORCID 0000-0003-0976-5504
Matteo ScopettiDepartment of Medical Surgical Sciences and Translational Medicine, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0002-7259-3090
Paola FratiDepartment of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-0358-7965
Vittorio FineschiDepartment of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-1686-3236
Sapienza University of Rome · ITUniversity of Trieste · ITCTO Andrea Alesini · ITMinistry of Interior · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOver the years, forensic pathology has registered the spread of new methods of suicide, such as the ingestion of sodium nitrite. Sodium nitrite causes increased methemoglobin, resulting in systemic hypoxia, metabolic acidosis, and cyanosis. Since sodium nitrite is a preservative, the ingestion of foods containing an excessive amount of this substance can also cause acute intoxication up to death. The present review is aimed at guiding health professionals in the identification and management of sodium-nitrite-related intoxications and deaths.

methodsA systematic literature search was carried out on PubMed by following the PRISMA statement's criteria. A total of 35 studies with 132 cases were enrolled, and the data were cataloged in Microsoft Excel. To establish the causal correlation between sodium nitrite ingestion and death, the Naranjo Adverse Drug Reaction Probability Scale was used.

resultsIn addition to the small number of cases that have currently been published, the study demonstrated that there was a general methodological discrepancy in the diagnostic process. However, some interesting results have emerged, especially in post-mortem diagnostics.

conclusionSodium-nitrite-related deaths represent a challenge for forensic pathologists; therefore, it is important to promptly recognize the essential features and perform the necessary and unrepeatable examinations for the correct diagnosis of the cause of death.

Indexed as

MethemoglobinemiaSuicideCyanosisHumansSodiumSodium NitriteSodiumSodium Nitriteautopsy findingsfatal methemoglobinemiaforensic pathologypost-mortem investigationspost-mortem toxicologysodium nitritesuicide

Identifiers

PMID36360874
PMCPMC9654862
OpenAlexW4307423230

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.