Evidence map›Paper›PMID 36364362›Full record

ArticleMolecules (Basel, Switzerland)2022

Antibodies-Abzymes with Antioxidant Activities in Two Th and 2D2 Experimental Autoimmune Encephalomyelitis Mice during the Development of EAE Pathology.

Anna S Tolmacheva, Kseniya S Aulova, Andrey E Urusov, Vasiliy B Doronin, Georgy A Nevinsky

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Oxidative Stress Markers in Multiple Sclerosis.International journal of molecular sciences · 2024
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anna S TolmachevaInstitute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Kseniya S AulovaInstitute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0001-6972-9068
Andrey E UrusovInstitute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Vasiliy B DoroninInstitute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Georgy A NevinskyInstitute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.ORCID 0000-0002-4988-8923
Institute of Chemical Biology and Fundamental Medicine · RU

Funding

Russian Science Foundation 22-15-00103
6 · The paper itself

Abstract

The exact mechanisms of multiple sclerosis development are still unknown. However, the development of EAE (experimental autoimmune encephalomyelitis) in Th and 2D2 mice is associated with the infringement of the differentiation profiles of bone marrow hematopoietic stem cells which are bound with the production of compounds that are harmful for human autoantibodies-abzymes that hydrolyze myelin oligodendrocyte glycoprotein, myelin basic protein, and DNA. It showed that autoimmune patients' antioxidant IgG antibodies oxidise some compounds due to their peroxidase (H

Indexed as

Antibodies, CatalyticEncephalomyelitis, Autoimmune, ExperimentalAnimalsAntioxidantsBenzothiazolesHumansHydrogen PeroxideImmunoglobulin GMiceMice, Inbred C57BLMyelin-Oligodendrocyte GlycoproteinOxidoreductasesPeroxidasesSulfonic Acids2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acidAntibodies, CatalyticAntioxidantsBenzothiazolesHydrogen PeroxideImmunoglobulin GMyelin-Oligodendrocyte GlycoproteinOxidoreductasesPeroxidasesSulfonic Acidscatalytic antibodiesEAE modelperoxidase and oxidoreductase activitiesTh and 2D2 mice

Identifiers

PMID36364362
PMCPMC9656754
OpenAlexW4308331309

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.