Evidence map›Paper›PMID 36364703›Full record

ArticleNutrients2022

The Genetic Variability of Members of the SLC38 Family of Amino Acid Transporters (

Paolina Crocco, Serena Dato, Alberto Montesanto, Anna Rita Bonfigli, Roberto Testa, Fabiola Olivieri, Giuseppe Passarino, Giuseppina Rose

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Paolina CroccoDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
Serena DatoDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
Alberto MontesantoDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.
Anna Rita BonfigliScientific Direction, IRCCS INRCA, 60121 Ancona, Italy.ORCID 0000-0002-9619-0181
Roberto TestaClinic of Laboratory and Precision Medicine, IRCCS INRCA, 60121 Ancona, Italy.ORCID 0000-0001-8308-7663
Fabiola OlivieriClinic of Laboratory and Precision Medicine, IRCCS INRCA, 60121 Ancona, Italy.ORCID 0000-0002-9606-1144
Giuseppe PassarinoDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.ORCID 0000-0003-4701-9748
Giuseppina RoseDepartment of Biology, Ecology and Earth Sciences, University of Calabria, 87036 Rende, Italy.ORCID 0000-0002-4264-4184
University of Calabria · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITMarche Polytechnic University · IT

Funding

Ministry of Education Italy PON ARS01_00568
6 · The paper itself

Abstract

Type 2 Diabetes (T2D) is a metabolic disease associated with long-term complications, with a multifactorial pathogenesis related to the interplay between genetic and modifiable risk factors, of which nutrition is the most relevant. In particular, the importance of proteins and constitutive amino acids (AAs) in disease susceptibility is emerging. The ability to sense and respond to changes in AA supplies is mediated by complex networks, of which AA transporters (AATs) are crucial components acting also as sensors of AA availability. This study explored the associations between polymorphisms in selected AATs genes and T2D and vascular complications in 433 patients and 506 healthy controls. Analyses revealed significant association of

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2Amino AcidsAmino Acid Transport SystemsHumansLeucineMechanistic Target of Rapamycin Complex 1Amino AcidsAmino Acid Transport SystemsLeucineMechanistic Target of Rapamycin Complex 1amino acid availabilityamino acid sensingamino acid transportersdiabetes complicationsgenetic variabilitymTORC1 pathwaySLC38 familyType 2 Diabetes

Identifiers

PMID36364703
PMCPMC9654215
OpenAlexW4307262301

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.