ReviewNutrients2022
Fluid Overload and Tissue Sodium Accumulation as Main Drivers of Protein Energy Malnutrition in Dialysis Patients.
Review in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Prognostic value of valve calcification and high cardiothoracic ratio for major adverse cardiovascular events and mortality in hemodialysis patients.Renal failure · 2026Article
- Multi-Omics Analysis of PBMCs Revealed Distinct Biological Differences Between Hemodialysis and Peritoneal Dialysis.International journal of molecular sciences · 2026Article
- Best Evidence Summary for Volume Management of Patients With Heart and Kidney Comorbidity.Nursing open · 2026Review
- The impact of nutritional management on the growth and nutritional status of children on regular hemodialysis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Association between lactate-to-albumin ratio and clinical outcomes in perioperative patients with chronic kidney disease: a retrospective cohort study based on INSPIRE database.Clinical and experimental nephrology · 2026Article
- Molecular frontiers in hemodialysis: unraveling the role of membranes in gene expression, epigenetics, and inflammatory pathways.International urology and nephrology · 2025Review
- Association Between the Malnutrition Status and Adverse Cardiovascular Outcomes in Patients With Obstructive Sleep Apnea and Acute Coronary Syndrome.Journal of the American Heart Association · 2025Article
- Latent profile analysis of nutrition knowledge, attitudes, and practices and their influencing factors in maintenance hemodialysis patients.Scientific reports · 2025Article
- Dietary energy intake predicts mortality in Chinese patients with peritoneal dialysis: a single-center 18 years' follow-up study.BMC nephrology · 2025Article
- A Randomized Controlled Clinical Trial of Individualized Patient Education on Hemodialysis Adequacy and Interdialytic Weight Gain.Journal of caring sciences · 2025Article
- Hemoincompatibility in Hemodialysis-Related Therapies and Their Health Economic Perspectives.Journal of clinical medicine · 2024Article
- Predictors of excess fluid volume in hemodialysis patients: an observational study.Revista brasileira de enfermagem · 2024Observational
- Review
- Clinical Significance of Nutritional Status, Inflammation, and Body Composition in Elderly Hemodialysis Patients-A Case-Control Study.Nutrients · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein energy malnutrition is recognized as a leading cause of morbidity and mortality in dialysis patients. Protein-energy-wasting process is observed in about 45% of the dialysis population using common biomarkers worldwide. Although several factors are implicated in protein energy wasting, inflammation and oxidative stress mechanisms play a central role in this pathogenic process. In this in-depth review, we analyzed the implication of sodium and water accumulation, as well as the role of fluid overload and fluid management, as major contributors to protein-energy-wasting process. Fluid overload and fluid depletion mimic a tide up and down phenomenon that contributes to inducing hypercatabolism and stimulates oxidation phosphorylation mechanisms at the cellular level in particular muscles. This endogenous metabolic water production may contribute to hyponatremia. In addition, salt tissue accumulation likely contributes to hypercatabolic state through locally inflammatory and immune-mediated mechanisms but also contributes to the perturbation of hormone receptors (i.e., insulin or growth hormone resistance). It is time to act more precisely on sodium and fluid imbalance to mitigate both nutritional and cardiovascular risks. Personalized management of sodium and fluid, using available tools including sodium management tool, has the potential to more adequately restore sodium and water homeostasis and to improve nutritional status and outcomes of dialysis patients.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.