Evidence mapPaperPMID 36367687Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2022

Renal TLR-7/TNF-α pathway as a potential female-specific mechanism in the pathogenesis of autoimmune-induced hypertension.

Sarika Chaudhari, Bradley M D'Souza, Jessica Y Morales, Cassandra M Young-Stubbs, Caroline G Shimoura, Rong Ma, Keisa W Mathis

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. PTPN2 Negatively Regulates Macrophage Immune Responses and Cellular Bioenergetics.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  6. I-mfa, Mesangial Cell TRPC1 Channel, and Regulation of GFR.Journal of the American Society of Nephrology : JASN · 2025
    Article
  7. Steering toward new horizons: a vision for the future of theAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
  8. Article
  9. Sex as a biological variable for cardiovascular physiology.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  10. Article
  11. Article
  12. A song of AAs and fire: divergent sex-dependent renal inflammatory mechanisms in hypertensive SLE mice.American journal of physiology. Heart and circulatory physiology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sarika ChaudhariDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.ORCID 0000-0002-2590-6365
Bradley M D'SouzaDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
Jessica Y MoralesDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.ORCID 0000-0002-3250-0099
Cassandra M Young-StubbsDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
Caroline G ShimouraDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.
Rong MaDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.ORCID 0000-0002-5896-9178
Keisa W MathisDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, Texas.ORCID 0000-0003-0247-910X
University of North Texas · US

Funding

Control of Renal Inflammation in HypertensionR01HL153703 · UT SOUTHWESTERN MEDICAL CENTER · 2025 to 2025
$561k
Store-operated Ca2+ signaling in kidney glomerular mesangial cellsR01DK115424 · NIDDK · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI RONG MA · 2021 to 2021
$329k
Neuroimmune Mechanisms Involved in the Pathogenesis of Hypertension and Renal InjuryK01HL139859 · NHLBI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI KEISA WILLIAMS MATHIS · 2022 to 2022
$154k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL153703NHLBI NIH HHS K01 HL139859NHLBI NIH HHS R01 HL153703NIDDK NIH HHS R01 DK079968NIDDK NIH HHS R01 DK115424
6 · The paper itself

Abstract

Hypertension is prevalent in patients with systemic lupus erythematosus (SLE). The goal of the current study is to track the pathogenesis of hypertension and renal injury in SLE, identify contributory mechanisms, and highlight differences in disease development among sexes. Mean arterial pressure was measured in conscious male and female SLE (

Indexed as

HypertensionTumor Necrosis Factor-alphaAnimalsFemaleKidneyMaleMiceSex CharacteristicsTumor Necrosis Factor-alphablood pressurerenal hemodynamicsrenal injurysystemic lupus erythematosusToll-like receptor 7

Identifiers

PMID36367687
PMCPMC9744658
OpenAlexW4308772610

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.