Evidence map›Paper›PMID 36368294›Full record

ReviewCurrent opinion in microbiology2023

Recent insights into type-3 secretion system injectisome structure and mechanism of human enteric pathogens.

Poyin Chen, Marcia B Goldberg

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. EnteropathogenicMicroorganisms · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Poyin ChenDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Microbiology, Harvard Medical School, Boston, MA, USA.
Marcia B GoldbergDivision of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Microbiology, Harvard Medical School, Boston, MA, USA; Broad Institute, Cambridge, MA, USA. Electronic address: marcia.goldberg@mgh.harvard.edu.
Broad Institute · USMassachusetts General Hospital · US

Funding

INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1M
Molecular signaling in Shigella disseminationR01AI081724 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 2010 to 2026
$7.1M
Organization and function of Shigella IpaB within plasma membrane translocon pores.F32AI147549 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, POYIN · 2020 to 2022
$208k
NIAID NIH HHS F32 AI147549NIAID NIH HHS R01 AI081724NIAID NIH HHS T32 AI007061
6 · The paper itself

Abstract

Type-3 secretion system injectisomes are multiprotein complexes that translocate bacterial effector proteins from the cytoplasm of gram-negative bacteria directly into the cytosol of eukaryotic host cells. These systems are present in more than 30 bacterial species, including numerous human, animal, and plant pathogens. We review recent discoveries of structural and molecular mechanisms of effector protein translocation through the injectisomes and recent advances in the understanding of mechanisms of activation of effector protein secretion.

Indexed as

Bacterial ProteinsType III Secretion SystemsAnimalsEukaryotic CellsGram-Negative BacteriaHumansProtein TransportBacterial ProteinsType III Secretion Systems

Identifiers

PMID36368294
PMCPMC10510281
OpenAlexW4308567032

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.