ArticleNeuroImage2022
Cortical myelin profile variations in healthy aging brain: A T1w/T2w ratio study.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 23 citations in OpenAlex.
- Physical Activity Is Associated With Age-Related Differences in Hippocampal Macrostructure and Microstructure in Middle-Aged and Older Adults.Hippocampus · 2026Article
- Aging and metabolism contribute separately to brain-body health.PLoS biology · 2026Article
- The In Vivo Microstructural Profile of Human Hippocampal Subfield CA1 and Its Relation to Memory Performance.Human brain mapping · 2026Article
- A DERIVED RELAXATION CONTRAST FROM SYNTHETIC MRI FOR DETECTING NETWORK MICROSTRUCTURAL VULNERABILITY.bioRxiv : the preprint server for biology · 2026Article
- The T1-Weighted/T2-Weighted Ratio as an In Vivo Proxy for Reduced Intracortical Myelin Content in Youth With RASopathies: A Cross-Sectional Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Prenatal and early postnatal periods differentially shape the maturation of human cortical microstructure and myelin.PLoS biology · 2026Article
- Imaging Developmental Trajectories of Laminar Magnetic Susceptibility Throughout Adulthood in Human Brain Cortex.Human brain mapping · 2025Article
- T1w/T2w ratio suggests reduced intracortical myelin content in youth with RASopathies.medRxiv : the preprint server for health sciences · 2025Article
- Humans have a longer period of cortical maturation across depth and hierarchy than macaques.PLoS biology · 2025Article
- Complementary MR measures of white matter and their relation to cardiovascular health and cognition.Scientific reports · 2025Article
- Association between cardiorespiratory fitness and total brain myelin volume among older adults.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Article
- Myelination across cortical hierarchies and depths in humans and macaques.bioRxiv : the preprint server for biology · 2025Article
- Comparative Sensitivity of MRI Indices for Myelin Assessment in Spinal Cord Regions.Tomography (Ann Arbor, Mich.) · 2025Article
- Mild traumatic brain injury increases cortical iron: evidence from individual susceptibility mapping.Brain communications · 2025Article
- Different Grey Matter Microstructural Patterns in Cognitively Healthy Versus Typical Ageing Healthy Versus Typical Brain Ageing.NMR in biomedicine · 2025Article
- So You Want to Image Myelin Using MRI: Magnetic Susceptibility Source Separation for Myelin Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Review
- Quantitative MRI at 7-Tesla reveals novel frontocortical myeloarchitecture anomalies in major depressive disorder.Translational psychiatry · 2024Article
- Depth- and curvature-based quantitative susceptibility mapping analyses of cortical iron in Alzheimer's disease.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Aging Brain from a Lifespan Perspective.Current topics in behavioral neurosciences · 2024Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Demyelination is observed in both healthy aging and age-related neurodegenerative disorders. While the significance of myelin within the cortex is well acknowledged, studies focused on intracortical demyelination and depth-specific structural alterations in normal aging are lacking. Using the recently available Human Connectome Project Aging dataset, we investigated intracortical myelin in a normal aging population using the T1w/T2w ratio. To capture the fine changes across cortical depths, we employed a surface-based approach by constructing cortical profiles traveling perpendicularly through the cortical ribbon and sampling T1w/T2w values. The curvatures of T1w/T2w cortical profiles may be influenced by differences in local myeloarchitecture and other tissue properties, which are known to vary across cortical regions. To quantify the shape of these profiles, we parametrized the level of curvature using a nonlinearity index (NLI) that measures the deviation of the profile from a straight line. We showed that NLI exhibited a steep decline in aging that was independent of local cortical thinning. Further examination of the profiles revealed that lower T1w/T2w near the gray-white matter boundary and superficial cortical depths were major contributors to the apparent NLI variations with age. These findings suggest that demyelination and changes in other T1w/T2w related tissue properties in normal aging may be depth-specific and highlight the potential of NLI as a unique marker of microstructural alterations within the cerebral cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.