Evidence map›Paper›PMID 36369488›Full record

ReviewNature reviews. Neurology2022

Social determinants of health in multiple sclerosis.

Ruth Dobson, Dylan R Rice, Marie D'hooghe, Rachel Horne, Yvonne Learmonth, Farrah J Mateen, Claudia H Marck, Saúl Reyes, Mitzi Joi Williams, Gavin Giovannoni and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  12. Assessing Unmet Social Needs in Multiple Sclerosis Care in Australia: A Qualitative Assessment of Feasibility, Barriers and Enablers.Health expectations : an international journal of public participation in health care and health policy · 2026
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ruth DobsonPreventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK. ruth.dobson@qmul.ac.uk.ORCID 0000-0002-2993-585X
Dylan R RiceDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Marie D'hoogheDepartment of Neurology, National MS Center, Melsbroek, Belgium.ORCID 0000-0002-0917-4176
Rachel HornePreventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Yvonne LearmonthDiscipline of Exercise Science, Murdoch University, Perth, WA, Australia.
Farrah J MateenDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-4293-8115
Claudia H MarckDisability and Health Unit, Melbourne School of Population and Global Health, University of Melbourne, VIC, Australia.
Saúl ReyesDepartment of Neurology, Fundación Santa Fe de Bogotá, Bogotá, Colombia.
Mitzi Joi WilliamsJoi Life Wellness MS Center, Smyrna, GA, USA.
Gavin GiovannoniPreventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID 0000-0001-9995-1700
Helen L FordDepartment of Neurology, Centre for Neurosciences, Leeds Teaching Hospitals, Leeds, UK.ORCID 0000-0002-4156-5046

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Social determinants of health are the conditions in which people are born, grow, live, work and age. These circumstances are the non-medical factors that influence health outcomes. Evidence indicates that health behaviours, comorbidities and disease-modifying therapies all contribute to multiple sclerosis (MS) outcomes; however, our knowledge of the effects of social determinants - that is, the 'risks of risks' - on health has not yet changed our approach to MS. Assessing and addressing social determinants of health could fundamentally improve health and health care in MS; this approach has already been successful in improving outcomes in other chronic diseases. In this narrative Review, we identify and discuss the body of evidence supporting an effect of many social determinants of health, including racial background, employment and social support, on MS outcomes. It must be noted that many of the published studies were subject to bias, and screening tools and/or practical interventions that address these social determinants are, for the most part, lacking. The existing work does not fully explore the potential bidirectional and complex relationships between social determinants of health and MS, and the interpretation of findings is complicated by the interactions and intersections among many of the identified determinants. On the basis of the reviewed literature, we consider that, if effective interventions targeting social determinants of health were available, they could have substantial effects on MS outcomes. Therefore, funding for and focused design of studies to evaluate and address social determinants of health are urgently needed.

Indexed as

Multiple SclerosisHumansSocial Determinants of HealthSocial Support

Identifiers

PMID36369488
PMCPMC9651126

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.