Evidence map›Paper›PMID 36370097›Full record

ArticleNucleic acids research2023

CAMPR4: a database of natural and synthetic antimicrobial peptides.

Ulka Gawde, Shuvechha Chakraborty, Faiza Hanif Waghu, Ram Shankar Barai, Ashlesha Khanderkar, Rishikesh Indraguru, Tanmay Shirsat, Susan Idicula-Thomas

Abstract read
In one paragraph

Article in Nucleic acids research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Artificial intelligence catalyzes antimicrobial peptide design.Synthetic and systems biotechnology · 2027
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70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ulka GawdeBiomedical Informatics Centre, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, Maharashtra, India.
Shuvechha ChakrabortyBiomedical Informatics Centre, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, Maharashtra, India.
Faiza Hanif WaghuBiomedical Informatics Centre, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, Maharashtra, India.
Ram Shankar BaraiBiomedical Informatics Centre, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, Maharashtra, India.
Ashlesha KhanderkarDepartment of Bioinformatics, Guru Nanak Khalsa College, Nathalal Parekh Marg, Matunga, Mumbai 400019, Maharashtra, India.
Rishikesh IndraguruDepartment of Bioinformatics, Guru Nanak Khalsa College, Nathalal Parekh Marg, Matunga, Mumbai 400019, Maharashtra, India.
Tanmay ShirsatBiomedical Informatics Centre, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, Maharashtra, India.
Susan Idicula-ThomasBiomedical Informatics Centre, ICMR-National Institute for Research in Reproductive and Child Health, Mumbai 400012, Maharashtra, India.ORCID 0000-0003-3766-6757

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There has been an exponential increase in the design of synthetic antimicrobial peptides (AMPs) for its use as novel antibiotics. Synthetic AMPs are substantially enriched in residues with physicochemical properties known to be critical for antimicrobial activity; such as positive charge, hydrophobicity, and higher alpha helical propensity. The current prediction algorithms for AMPs have been developed using AMP sequences from natural sources and hence do not perform well for synthetic peptides. In this version of CAMP database, along with updating sequence information of AMPs, we have created separate prediction algorithms for natural and synthetic AMPs. CAMPR4 holds 24243 AMP sequences, 933 structures, 2143 patents and 263 AMP family signatures. In addition to the data on sequences, source organisms, target organisms, minimum inhibitory and hemolytic concentrations, CAMPR4 provides information on N and C terminal modifications and presence of unusual amino acids, as applicable. The database is integrated with tools for AMP prediction and rational design (natural and synthetic AMPs), sequence (BLAST and clustal omega), structure (VAST) and family analysis (PRATT, ScanProsite, CAMPSign). The data along with the algorithms of CAMPR4 will aid to enhance AMP research. CAMPR4 is accessible at http://camp.bicnirrh.res.in/.

Indexed as

Antimicrobial Cationic PeptidesAntimicrobial PeptidesAlgorithmsAnti-Bacterial AgentsDatabases, FactualAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial Peptides

Identifiers

PMID36370097
PMCPMC9825550

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.