Evidence map›Paper›PMID 36370200›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2023

Anti-inflammatory effects of new human histamine H

Ewelina Honkisz-Orzechowska, Katarzyna Popiołek-Barczyk, Zuzanna Linart, Jadwiga Filipek-Gorzała, Anna Rudnicka, Agata Siwek, Tobias Werner, Holger Stark, Jakub Chwastek, Katarzyna Starowicz and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. AR71, Histamine HInternational journal of molecular sciences · 2024
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Ewelina Honkisz-OrzechowskaFaculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688, Kraków, Poland. ewelina.honkisz@uj.edu.pl.
Katarzyna Popiołek-BarczykDepartment of Neurochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland.
Zuzanna LinartFaculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688, Kraków, Poland.
Jadwiga Filipek-GorzałaFaculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688, Kraków, Poland.
Anna RudnickaFaculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688, Kraków, Poland.
Agata SiwekFaculty of Pharmacy, Department of Pharmacobiology, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688, Kraków, Poland.
Tobias WernerInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Duesseldorf, Universitaetsstr. 1, 40225, Duesseldorf, Germany.
Holger StarkInstitute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Duesseldorf, Universitaetsstr. 1, 40225, Duesseldorf, Germany.
Jakub ChwastekDepartment of Neurochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland.
Katarzyna StarowiczDepartment of Neurochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland.
Katarzyna Kieć-KononowiczFaculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688, Kraków, Poland.
Dorota ŁażewskaFaculty of Pharmacy, Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical College in Kraków, Medyczna 9, 30-688, Kraków, Poland. dorota.lazewska@uj.edu.pl.ORCID http://orcid.org/0000-0001-8454-4440
Jagiellonian University · PLMaj Institute of Pharmacology · PLHeinrich Heine University Düsseldorf · DE

Funding

Narodowe Centrum Nauki UMO-2019/35/D/NZ7/01042Narodowym Centrum Nauki UMO-2016/23/B/NZ7/02327Uniwersytet Jagielloński Collegium Medicum N42/DBS/000124Uniwersytet Jagielloński Collegium Medicum N42/DBS/000197
6 · The paper itself

Abstract

objectiveMicroglia play an important role in the neuroinflammation developed in response to various pathologies. In this study, we examined the anti-inflammatory effect of the new human histamine H MATERIAL AND

methodsThe affinity of flavonoids (E243 -flavone and IIIa-IIIc-chalcones) for human H

resultsChalcone derivatives showed high affinity at human H

conclusionsThese results emphasize the importance of further research to accurately identify the anti-inflammatory mechanism of action of chalcones.

Indexed as

ChalconesHistamineAnimalsAnti-Inflammatory AgentsCytokinesFlavonoidsHumansInflammationLipopolysaccharidesMiceMicrogliaNeuroinflammatory DiseasesReceptors, HistamineAnti-Inflammatory AgentsChalconesCytokinesFlavonoidsHistamineLipopolysaccharidesReceptors, HistamineChalconeHistamine H3 receptorMicrogliaNeuroinflammation

Identifiers

PMID36370200
PMCPMC9925557
OpenAlexW4308834563

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.