ArticleAnnals of intensive care2022
Right ventricular free wall longitudinal strain is independently associated with mortality in mechanically ventilated patients with COVID-19.
Article in Annals of intensive care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04764032 (Right Ventricular Dysfunction in Ventilated Patients With COVID-19), which is not on this map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Right Ventricular Dysfunction in Ventilated Patients With COVID-19
Who cites it
11 citing papers in PubMed.
- Review
- Echocardiography in the Ventilated Patient: What the Clinician Has to Know.Journal of clinical medicine · 2024Review
- Navigating Heart-Lung Interactions in Mechanical Ventilation: Pathophysiology, Diagnosis, and Advanced Management Strategies in Acute Respiratory Distress Syndrome and Beyond.Journal of clinical medicine · 2024Article
- MRI of cardiac involvement in COVID-19.The British journal of radiology · 2024Review
- Characterizing Cardiac Function in ICU Survivors of Sepsis: A Pilot Study Protocol.CHEST critical care · 2024Article
- Monitoring of the right ventricular responses to pressure overload: prognostic value and usefulness of echocardiography for clinical decision-making.Cardiovascular diagnosis and therapy · 2024Review
- Right ventricular injury in critically ill patients with COVID-19: a descriptive study with standardized echocardiographic follow-up.Annals of intensive care · 2024Article
- Current trends and latest developments in echocardiographic assessment of right ventricular function: load dependency perspective.Frontiers in cardiovascular medicine · 2024Review
- Multimodality Cardiac Imaging in COVID-19 Infection.Medicina (Kaunas, Lithuania) · 2023Review
- Cardiovascular Subphenotypes in ARDS: Diagnostic and Therapeutic Implications and Overlap with Other ARDS Subphenotypes.Journal of clinical medicine · 2023Review
- Relationship of right ventricular functions with in-hospital and 1 year later mortality in patients hospitalized for COVID-19 pneumonia.Annals of thoracic medicineArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundRight ventricular (RV) dysfunction has been commonly reported in patients with Coronavirus disease 2019 (COVID-19), and is associated with mortality in mixed cohorts of patients requiring and not requiring invasive mechanical ventilation (IMV). Using RV-speckle tracking echocardiography (STE) strain analysis, we aimed to identify the prevalence of RV dysfunction (diagnosed by abnormal RV-STE) in patients with COVID-19 that are exclusively undergoing IMV, and assess association between RV dysfunction and 30 day mortality. We performed a prospective multicentre study across 10 ICUs in Scotland from 2/9/20 to 22/3/21. One-hundred-and-four echocardiography scans were obtained from adult patients at a single timepoint between 48 h after intubation, and day 14 of intensive care unit admission. We analysed RV-STE using RV free-wall longitudinal strain (RVFWLS), with an abnormal cutoff of > -20%. We performed survival analysis using Kaplan-Meier, log rank, and multivariate cox-regression (prespecified covariates were age, gender, ethnicity, severity of illness, and time since intubation).
resultsNinety-four/one-hundred-and-four (90.4%) scans had images adequate for RVFWLS. Mean RVFWLS was -23.0% (5.2), 27/94 (28.7%) of patients had abnormal RVFWLS. Univariate analysis with Kaplan-Meier plot and log-rank demonstrated that patients with abnormal RVFWLS have a significant association with 30-day mortality (p = 0.047). Multivariate cox-regression demonstrated that abnormal RVFWLS is independently associated with 30-day mortality (Hazard-Ratio 2.22 [1.14-4.39], p = 0.020).
conclusionsAbnormal RVFWLS (> -20%) is independently associated with 30-day mortality in patients with COVID-19 undergoing IMV. Strategies to prevent RV dysfunction, and treatment when identified by RVFWLS, may be of therapeutic benefit to these patients.
trial registrationRetrospectively registered 21st Feb 2021. CLINICALTRIALS: gov Identifier: NCT04764032.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.