Evidence map›Paper›PMID 36382136›Full record

ReviewRegenerative therapy2022

Regenerative medicine strategies for hair growth and regeneration: A narrative review of literature.

Yusuke Shimizu, Edward Hosea Ntege, Hiroshi Sunami, Yoshikazu Inoue

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Regenerative therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 3 pooled it
16.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 3 syntheses or guidelines pooled it, 115 citations in OpenAlex.

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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yusuke ShimizuDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Nakagami, Okinawa, 903-0215, Japan.
Edward Hosea NtegeDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Nakagami, Okinawa, 903-0215, Japan.
Hiroshi SunamiCenter for Advanced Medical Research, School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Nakagami, Okinawa, 903-0215, Japan.
Yoshikazu InoueDepartment of Plastic and Reconstructive Surgery, School of Medicine, Fujita Health University, 1-98, Dengakugakubo, Kutsukake, Toyoake, Aichi, 470-1192, Japan.
University of the Ryukyus · JPFujita Health University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hair loss, or alopecia, is associated with several psychosocial and medical comorbidities, and it remains an economic burden to individuals and the society. Alopecia is attributable to varied mechanisms and features a multifactorial predisposition, and the available conventional medical interventions have several limitations. Thus, several therapeutic strategies for alopecia in regenerative medicine are currently being explored, with increasing evidence suggesting that mesenchymal stem cell (MSC) implantation, MSC-derived secretome treatment, and blood-derived platelet-rich plasma therapies are potential treatment options. In this review, we searched the Cochrane Library, MEDLINE (PubMed), EMBASE, and Scopus using various combinations of terms, such as "stem cell," "alopecia," "hair loss," "Androgenetic alopecia," "male-pattern hair loss," "female-pattern hair loss," "regenerative hair growth," "cell therapy," "mesenchymal stem cells," "MSC-derived extracellular vesicles," "MSC-derived exosomes," and "platelet-rich plasma" and summarized the most promising regenerative treatments for alopecia. Moreover, further opportunities of improving efficacy and innovative strategies for promoting clinical application were discussed.

Indexed as

AA, alopecia areataAA-PRP, autologous activated PRPAD-MSCs, adipose tissue derived mesenchymal stromal cellsADRCs, adipose-derived regenerative cellsADSVCs, adipose-derived stromal vascular cellsAE, anagen effluviumAGA, androgenetic alopeciaAlopeciaBM-MSCs, bone marrow derived mesenchymal stromal cellsCA, cicatricial alopeciaCD, cluster of differentiationCM, conditioned mediumDHT, dihydrotestosteroneECM, extracellular matrixEGF, epidermal growth factorEMA, European Medicines AgencyEMI, epithelial–mesenchymal interactionEVs, extracellular vesiclesFDA, United States Food and Drug AdministrationFGF, fibroblast growth factorFPHL, female-pattern hair lossGMP, good manufacturing practiceGVHD, graft-versus-host diseaseHair follicle regenerationHair lossHair regrowthhDPCs, human dermal papilla cellsHF, hair follicleHFSCs, hair follicle stem cellshUC-MSCs, umbilical cord blood-derived mesenchymal stromal cellsIGF, insulin-like growth factorIL, interleukiniPSC-MSCs, induced pluripotent stem cells derived mesenchymal stem cellsiPSCs, induced pluripotent stem cellsISSCR, The International Society for Stem Cell ResearchKGF, keratinocyte growth factorLA, lipedematous alopeciaLS, lipedematous scalpMAPK/ERK, mitogen-activated protein kinases or extracellular signal-regulated kinasesMCP1, monocyte chemoattractant protein 1MMP, matrix metalloproteinaseMPHL, male-pattern hair lossMSCs, mesenchymal stromal cellsnon-CA, non-cicatricial alopeciaOS, oxidative stressPDGF, platelet-derived growth factorPG, prostaglandinPI3K/Akt, phosphatidylinositol 3-kinase/protein kinase BPMD-Act, pharmaceuticals and Medical Devices Agency-ActPRP, platelet-rich plasmaROS, reactive oxygen speciesSALT, severity of alopecia toolSCs, stem cellsSLE, systemic lupus erythematosusStem cell extracellular vesiclesStem cell therapySVF, stromal vascular fractionTA, traction alopeciaTE, telogen effluviumTGF-β, transforming growth factor βTh, T helperTNF, tumor necrosis factorTreg, regulatory T cellsTTM, trichotillomaniaVEGF, vascular endothelial growth factorWnt, wingless/integrated-1

Identifiers

PMID36382136
PMCPMC9637724
OpenAlexW4307898205

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.