Evidence map›Paper›PMID 36383412›Full record

ArticleeLife2022

The

Nehal Gupta, Hanbing Song, Wei Wu, Rovingaile K Ponce, Yone K Lin, Ji Won Kim, Eric J Small, Felix Y Feng, Franklin W Huang, Ross A Okimoto

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. ETS‑1/ETS‑2 transcription factors in CVD (Review).International journal of molecular medicine · 2026
    Review
  2. Variable thresholds for phosphorylation targets of the ERK signaling pathway.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  10. TheeLife · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Nehal GuptaDepartment of Medicine, University of California, San Francisco, United States.ORCID 0000-0002-8931-5759
Hanbing SongDepartment of Medicine, University of California, San Francisco, United States.
Wei WuDepartment of Medicine, University of California, San Francisco, United States.
Rovingaile K PonceDepartment of Medicine, University of California, San Francisco, United States.
Yone K LinDepartment of Medicine, University of California, San Francisco, United States.
Ji Won KimDepartment of Medicine, University of California, San Francisco, United States.
Eric J SmallDepartment of Medicine, University of California, San Francisco, United States.
Felix Y FengDepartment of Medicine, University of California, San Francisco, United States.
Franklin W HuangDepartment of Medicine, University of California, San Francisco, United States.ORCID 0000-0001-5447-0436
Ross A OkimotoDepartment of Medicine, University of California, San Francisco, United States.ORCID 0000-0002-4467-8476
UCSF Helen Diller Family Comprehensive Cancer Center · US

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alan Ashworth · 1999 to 2026
$209.7M
Therapeutic degradation of Capicua (CIC) fused oncoproteins in undifferentiated sarcomasR37CA255453 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Ross Okimoto · 2021 to 2026
$2.7M
Therapeutic rescue of the transcriptional repressor Capicua to inhibit lung cancer metastasisK08CA222625 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OKIMOTO, ROSS · 2018 to 2022
$887k
NCI NIH HHS K08 CA222625NCI NIH HHS P30 CA082103NCI NIH HHS R37 CA255453
6 · The paper itself

Abstract

Human prostate cancer can result from chromosomal rearrangements that lead to aberrant ETS gene expression. The mechanisms that lead to fusion-independent ETS factor upregulation and prostate oncogenesis remain relatively unknown. Here, we show that two neighboring transcription factors, Capicua (

Indexed as

DNA-Binding ProteinsProstateProstatic NeoplasmsRepressor ProteinsTranscription FactorsCarcinogenesisGene DeletionHumansMaleCIC protein, humanDNA-Binding ProteinsERF protein, humanETV1 protein, humanRepressor ProteinsTranscription Factorscancer biologyCapicuaERFETS transcription factorshumanprostate cancer

Identifiers

PMID36383412
PMCPMC9668335
OpenAlexW4309660098

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.