Evidence map›Paper›PMID 36384171›Full record

ArticleGene2023

Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells.

Cai Ping Koh, Avinash Govind Bahirvani, Chelsia Qiuxia Wang, Tomomasa Yokomizo, Cherry Ee Lin Ng, Linsen Du, Vinay Tergaonkar, Dominic Chih-Cheng Voon, Hiroaki Kitamura, Hiroki Hosoi and 11 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 4 countries.

Cai Ping KohCancer Science Institute of Singapore, National University of Singapore, Singapore 117456, Singapore; Department of Biochemistry, Faculty of Medicine, Quest International University, Perak 30250, Malaysia.
Avinash Govind BahirvaniCancer Science Institute of Singapore, National University of Singapore, Singapore 117456, Singapore.
Chelsia Qiuxia WangCancer Science Institute of Singapore, National University of Singapore, Singapore 117456, Singapore; Institute of Molecular and Cell Biology, A*STAR, Singapore 138673, Singapore.
Tomomasa YokomizoCancer Science Institute of Singapore, National University of Singapore, Singapore 117456, Singapore; International Research Center for Medical Sciences, Kumamoto University, Kumamoto 860-0811, Japan.
Cherry Ee Lin NgCancer Science Institute of Singapore, National University of Singapore, Singapore 117456, Singapore.
Linsen DuCancer Science Institute of Singapore, National University of Singapore, Singapore 117456, Singapore.
Vinay TergaonkarInstitute of Molecular and Cell Biology, A*STAR, Singapore 138673, Singapore.
Dominic Chih-Cheng VoonCancer Science Institute of Singapore, National University of Singapore, Singapore 117456, Singapore; Cancer Research Institute, Kanazawa University, Ishikawa 920-1192, Japan; Institute for Frontier Science Initiative, Kanazawa University, Ishikawa 920-1192, Japan.
Hiroaki KitamuraCancer Science Institute of Singapore, National University of Singapore, Singapore 117456, Singapore.
Hiroki HosoiCancer Science Institute of Singapore, National University of Singapore, Singapore 117456, Singapore; Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
Takashi SonokiDepartment of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
Mok Meng Huang MichelleCancer Science Institute of Singapore, National University of Singapore, Singapore 117456, Singapore.
Lii Jye TanDepartment of Forensic Medicine, Hospital Raja Permaisuri Bainun, Ipoh, Perak Daruk Ridzuan, Malaysia.
Akiko Niibori-NambuCancer Science Institute of Singapore, National University of Singapore, Singapore 117456, Singapore; Department of Tumor Genetics and Biology, Graduate School of Medical Sciences, Institute of Life Sciences, Kumamoto University, Kumamoto, Japan.
Yi ZhangDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, United States of America.
Archibald S PerkinsDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, United States of America.
Zakir HossainCancer Science Institute of Singapore, National University of Singapore, Singapore 117456, Singapore.
Daniel G TenenCancer Science Institute of Singapore, National University of Singapore, Singapore 117456, Singapore.
Yoshiaki ItoCancer Science Institute of Singapore, National University of Singapore, Singapore 117456, Singapore.
Byrappa VenkateshInstitute of Molecular and Cell Biology, A*STAR, Singapore 138673, Singapore. Electronic address: mcbbv@imcb.a-star.edu.sg.
Motomi OsatoCancer Science Institute of Singapore, National University of Singapore, Singapore 117456, Singapore; International Research Center for Medical Sciences, Kumamoto University, Kumamoto 860-0811, Japan; Department of Pediatrics, National University of Singapore, Singapore 119228, Singapore. Electronic address: csimo@nus.edu.sg.
National University of Singapore · SGNational University Cancer Institute, Singapore · SGAgency for Science, Technology and Research · SGUniversity of Rochester Medical Center · USInstitut Penyelidikan Veterinar · MYKumamoto University · JPWakayama Medical University · JP

Funding

Transcriptional and epigenetic heterogeneity of stem/progenitor cellsP01HL131477 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Jason Daniel Buenrostro · 2017 to 2026
$24.6M
NHLBI NIH HHS P01 HL131477
6 · The paper itself

Abstract

A cis-regulatory genetic element which targets gene expression to stem cells, termed stem cell enhancer, serves as a molecular handle for stem cell-specific genetic engineering. Here we show the generation and characterization of a tamoxifen-inducible CreER

Indexed as

Adult Stem CellsHematopoietic Stem CellsAnimalsCore Binding Factor Alpha 2 SubunitFetusGenetic EngineeringKineticsMiceMice, TransgenicCore Binding Factor Alpha 2 SubunitRunx1 protein, mouseAML1EnhancerHematopoietic stem cellLeukemia stem cellRUNX1

Identifiers

PMID36384171
PMCPMC10492510
OpenAlexW4309246338

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.