Evidence map›Paper›PMID 36384270›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2023

Blood Pressure Responses During Exercise: Physiological Correlates and Clinical Implications.

Matthew Nayor, Priya Gajjar, Venkatesh L Murthy, Patricia E Miller, Raghava S Velagaleti, Martin G Larson, Ramachandran S Vasan, Gregory D Lewis, Gary F Mitchell, Ravi V Shah

Open access · bronzeAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

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  4. Prognostic value of exercise blood pressure: role of fitness and exercise training.American journal of physiology. Heart and circulatory physiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Matthew Nayor *Cardiovascular Medicine Section (M.N., P.G., R.S. Vasan), Boston University School of Medicine, MA.ORCID 0000-0002-6993-9396
Priya GajjarCardiovascular Medicine Section (M.N., P.G., R.S. Vasan), Boston University School of Medicine, MA.
Venkatesh L MurthyDivision of Cardiovascular Medicine, Department of Medicine (V.L.M.), University of Michigan, Ann Arbor.ORCID 0000-0002-7901-1321
Patricia E MillerDepartment of Medicine, and Department of Biostatistics (P.E.M., M.G.L.), Boston University School of Medicine, MA.
Raghava S VelagaletiBoston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA (M.N., R.S. Vasan, M.G.L., R.S. Velagaleti).ORCID 0000-0002-2725-2692
Martin G LarsonDepartment of Medicine, and Department of Biostatistics (P.E.M., M.G.L.), Boston University School of Medicine, MA.
Ramachandran S VasanCardiovascular Medicine Section (M.N., P.G., R.S. Vasan), Boston University School of Medicine, MA.ORCID 0000-0001-7357-5970
Gregory D Lewis *Cardiology Division and Pulmonary Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (G.D.L.).ORCID 0000-0001-8108-8240
Gary F Mitchell *Cardiovascular Engineering, Inc, Norwood, MA (G.F.M.).ORCID 0000-0001-5643-3145
Ravi V Shah *Cardiovascular Medicine Section (M.N., P.G., R.S. Vasan), Boston University School of Medicine, MA.ORCID 0000-0002-4471-7156
Boston University · USMassachusetts General Hospital · USNorwood Hospital · USUniversity of Michigan · USVA Boston Healthcare System · US

Funding

FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN · 2019 to 2024
$29.8M
Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF SpectrumR01HL131029 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Gregory Dyer Lewis, Matthew G. Nayor · 2016 to 2026
$7.7M
Metabolic Responses to an Oral Mixed Meal Tolerance Test: Intra-individual changes, correlates, and prognostic significanceR01HL156975 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NAYOR, MATTHEW G. · 2021 to 2025
$3.3M
Characterization of Molecular and Physiologic Signatures of Impaired Multi-Organ System Reserve Capacity During Exercise in Heart Failure with Preserved Ejection FractionR01HL151841 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LEWIS, GREGORY DYER, SHAH, RAVI · 2020 to 2023
$2.7M
Molecular markers of early cardiometabolic health transitions in the CARDIA studyR01HL136685 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MURTHY, VENKATESH LOCHARLA, SHAH, RAVI · 2017 to 2021
$2.6M
Vascular Stiffness as a Precursor of Hypertension in a Middle-aged CohortR01HL126136 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MITCHELL, GARY FRANK, RAMACHANDRAN, VASAN S · 2015 to 2018
$2.6M
Characterization of Functional Iron Deficiency and Repletion in Heart Failure with Preserved Ejection FractionR01HL159514 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LEWIS, GREGORY DYER, MALHOTRA, RAJEEV · 2021 to 2024
$2.5M
Metabolic Signatures of Impaired Cardiorespiratory Fitness: Correlates, Prognostic Significance and Modulation with Exercise TrainingK23HL138260 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAYOR, MATTHEW G. · 2017 to 2021
$998k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
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NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS K23 HL138260NHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL126136NHLBI NIH HHS R01 HL131029NHLBI NIH HHS R01 HL136685NHLBI NIH HHS R01 HL151841NHLBI NIH HHS R01 HL156975NHLBI NIH HHS R01 HL159514
6 · The paper itself

Abstract

backgroundAbnormal blood pressure (BP) responses to exercise can predict adverse cardiovascular outcomes, but their optimal measurement and definitions are poorly understood. We combined frequently sampled BP during cardiopulmonary exercise testing with vascular stiffness assessment to parse cardiac and vascular components of exercise BP.

methodsCardiopulmonary exercise testing with BP measured every two minutes and resting vascular tonometry were performed in 2858 Framingham Heart Study participants. Linear regression was used to analyze sex-specific exercise BP patterns as a function of arterial stiffness (carotid-femoral pulse wave velocity) and cardiac-peripheral performance (defined by peak O

resultsOur sample was balanced by sex (52% women) with mean age 54±9 years and 47% with hypertension. We observed variability in carotid-femoral pulse wave velocity and peak O

conclusionsHigher peak exercise SBP reflects a complex trade-off between arterial stiffness and cardiac-peripheral performance that differs by sex. Studies of BP responses to exercise accounting for vascular and cardiac physiology may illuminate mechanisms of hypertension and clarify clinical interpretation of exercise BP.

Indexed as

Cardiovascular SystemHypertensionVascular StiffnessBlood PressureExercise TestFemaleHumansMaleMiddle AgedPulse Wave Analysisblood pressurecardiovascular diseaseexercise testvascular stiffnessworkload

Identifiers

PMID36384270
PMCPMC9780190
OpenAlexW4309246179

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.