Evidence map›Paper›PMID 36387439›Full record

ArticleHeliyon2022

Dose-related shifts in proteome and function of extracellular vesicles secreted by fetal neural stem cells following chronic alcohol exposure.

Dae D Chung, Marisa R Pinson, Amanda H Mahnke, Nihal A Salem, Khang T Le, Elizabeth A Payne, Tenley E Lehman, Susan T Weintraub, Rajesh C Miranda

Open access · goldAbstract read
In one paragraph

Article in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Fetal alcohol spectrum disorders.Nature reviews. Disease primers · 2023
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dae D ChungDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Bryan, TX, USA.
Marisa R PinsonDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Bryan, TX, USA.
Amanda H MahnkeDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Bryan, TX, USA.
Nihal A SalemDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Bryan, TX, USA.
Khang T LeDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Bryan, TX, USA.
Elizabeth A PayneDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Bryan, TX, USA.
Tenley E LehmanDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Bryan, TX, USA.
Susan T WeintraubDepartment of Biochemistry and Structural Biology, University of Texas, Health Science Center at San Antonio, San Antonio, TX, USA.
Rajesh C MirandaDepartment of Neuroscience and Experimental Therapeutics, Texas A&M University Health Science Center, Bryan, TX, USA.
Texas A&M Health Science Center · USThe University of Texas Health Science Center at San Antonio · US

Funding

From FASD to AUDs: Strategies for Preventing Alcohol AddictionsK00AA029955 · NIAAA · UNIVERSITY OF TEXAS AT AUSTIN · PI SALEM, NIHAL A · 2021 to 2024
$350k
Gag-like Proteins in exosome-mediated Neural Development and Fetal Alcohol Spectrum DisordersF30AA027698 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI PINSON, MARISA · 2019 to 2023
$179k
From FASD to AUDs: Strategies for Preventing Alcohol AddictionsF99NS113423 · NINDS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SALEM, NIHAL A · 2019 to 2019
$34k
NIAAA NIH HHS F30 AA027698NIAAA NIH HHS K00 AA029955NINDS NIH HHS F99 NS113423
6 · The paper itself

Abstract

Accumulating evidence indicates that extracellular vesicles (EVs) mediate endocrine functions and also pathogenic effects of neurodevelopmental perturbagens like ethanol. We performed mass-spectrometry on EVs secreted by fetal murine cerebral cortical neural stem cells (NSCs), cultured

Indexed as

AlcoholDevelopmentalExosomeExtracellular vesicleFetal alcohol spectrum disorderNeural stem cellPrenatal alcohol exposureProteomeSexWGCNA

Identifiers

PMID36387439
PMCPMC9649983
OpenAlexW4308034614

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.