ArticleInternational journal of sexual health : official journal of the World Association for Sexual Health2022
Effects of Erectile Dysfunction Drugs Use on T-cells and Immune Markers on Men Who Have Sex with Men.
Jee Won Park, Onyebuchi A Arah, Otoniel Martinez-Maza, Adrian S Dobs, Ken S Ho, Frank J Palella, Eric C Seaberg, Roger Detels
Open access · greenAbstract read
In one paragraphArticle in International journal of sexual health : official journal of the World Association for Sexual Health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors at 5 institutions in 1 country.
Jee Won ParkDepartment of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
Onyebuchi A ArahDepartment of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
Otoniel Martinez-MazaDavid Geffen UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Adrian S DobsDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ken S HoDepartment of Medicine, University of Pittsburgh, PA, USA.
Frank J PalellaDivision of Infectious Diseases, Feinberg School of Medicine of Northwestern University, Chicago, IL, USA.
Eric C SeabergDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Roger DetelsDepartment of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · USJohns Hopkins Medicine · USJohns Hopkins University · USNorthwestern University · USUniversity of Pittsburgh · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MNATURAL HISTORY OF AIDS IN HOMOSEXUAL MENU01AI035040 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DETELS, ROGER, MARTINEZ-MAZA, OTONIEL · 1993 to 2018
$75.2MVaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MSex differences in the role of multi-omicsin HIV-associated carotid artery atherosclerosisU01HL146193 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Stephen J Gange, Elizabeth Topper · 2019 to 2026
$35.8MClinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center - Admin Supplement: Vision and dual sensory loss in HIV-infected older adultsU01HL146201 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TODD T BROWN, Joseph B. Margolick · 2019 to 2026
$33.7MUniversity of Pittsburgh MWCCS Clinical Research SiteU01HL146208 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Bernard Jonas C Macatangay, CHARLES R RINALDO · 2019 to 2026
$32.2MStudy of Hearing and Balance in Middle Aged and Aging Men and Women in the MACS-WIHS Combined Cohort StudyU01HL146333 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Roger Detels, Matthew James Mimiaga · 2019 to 2026
$32.2MNorthwestern CORE Clinical Research Site: Trans-omics for HIV/AIDS ResearchU01HL146240 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Frank J Palella, Valentina Stosor · 2019 to 2026
$31.5MStatistics and Methods CoreR24HD041022 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUCHINSKY, MOSHE · 2001 to 2016
$10.1MPREMIERE: A PREdictive Model Index and Exchange REpositoryR01EB027650 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUI, ALEX · 2019 to 2023
$3.0MNCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001881NHLBI NIH HHS U01 HL146193NHLBI NIH HHS U01 HL146201NHLBI NIH HHS U01 HL146208NHLBI NIH HHS U01 HL146240NHLBI NIH HHS U01 HL146333NIAID NIH HHS P30 AI094189NIAID NIH HHS U01 AI035040NIBIB NIH HHS R01 EB027650NICHD NIH HHS R24 HD041022
6 · The paper itselfAbstract
Objective: Examine prospective relationships between erectile dysfunction (ED) drugs EDand CD4 and CD8 T-cells, and immune markers among men who have sex with men (MSM). Methods: Data from Multicenter AIDS Cohort Study, an observational prospective cohort study, with semi-annual follow-ups conducted in four U.S. centers from 1998 onwards was used. Marginal structural models using g-computation was fitted to estimate the mean differences for the effects of self-reported ED drug use on CD4 and CD8 T-cell outcomes and immune biomarkers. Results: Total of 1,391 men with HIV (MWH) and 307 men without HIV (MWOH) was included. Baseline mean CD4 cell count among MWH and MWOH was 499.9 cells/μL and 966.7 cells/μL, respectively. At baseline, 41.8% of MWH were virally suppressed. ED drug users reported a mean of 44.4 months of exposure to ED drugs. ED drug use was associated with increased CD4 cell outcomes among MWH but not MWOH. Mean differences in CD4 cell counts after 1 year of ED drug use was 57.6 cells/μL and increased to 117.7 after 10 years among MWH. CD8 counts were higher in ED drug users among MWH over 10 years than non-users; no consistent differences were found among MWOH. ED drug use appeared to reduce immune marker levels, such as IL-6 and increase markers, such as IL-10. We observed similar effects of ED drug use on biomarker levels among MWOH. Conclusion: Long-term use of ED drugs do not adversely affect immune function among MWH or MWOH. Future studies on the relationships between different types of ED drugs and effects on T-cell subtypes are warranted.
Indexed as
biomarkerscohort studiesmen who have sex with men (MSM)phosphodiesterase 5 inhibitorsT-lymphocytes
Identifiers
PMID36387612
PMCPMC9665348
OpenAlexW4282916590
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