Evidence map›Paper›PMID 36387846›Full record

ReviewFrontiers in endocrinology2022

Anti-obesity pharmacotherapy for treatment of pediatric type 2 diabetes: Review of the literature and lessons learned from adults.

Megan O Bensignor, Aaron S Kelly, Silva Arslanian

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Childhood Obesity: Insight into Kidney Involvement.International journal of molecular sciences · 2023
    Review
  6. Article
  7. Review
  8. From Metabolic Syndrome to Type 2 Diabetes in Youth.Children (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Megan O BensignorCenter for Pediatric Obesity Medicine, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States.
Aaron S KellyCenter for Pediatric Obesity Medicine, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States.
Silva ArslanianCenter for Pediatric Research in Obesity and Metabolism, Division of Pediatric Endocrinology and Metabolism, University of Pittsburgh Medical Center (UPMC) Children's Hospital, University of Pittsburgh, Pittsburgh, PA, United States.
University of Minnesota · USChildren's Hospital of Pittsburgh · US

Funding

Anti-obesity pharmacotherapy to decrease BMI and improve insulin sensitivity in adolescents with obesity and type 2 diabetesK23DK129721 · NIDDK · UNIVERSITY OF MINNESOTA · PI BENSIGNOR, MEGAN O · 2021 to 2025
$1.0M
NIDDK NIH HHS K23 DK129721
6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) in adolescents is a more rapidly progressive disease, associated with earlier and higher rates of microvascular complications than in adults. As obesity is a significant risk factor for T2DM development and progression, the American Diabetes Association (ADA) recommends anti-obesity medications (AOMs) as adjuvant therapy for adults with both T2DM and overweight/obesity. In adults, the addition of AOMs to a diabetes regimen can improve glycemic control, reduce weight, and decrease anti-diabetes medication use. The ADA recommends considering bariatric surgery for adolescents with T2DM who have a BMI >35 kg/m

Indexed as

Anti-Obesity AgentsBariatric SurgeryDiabetes Mellitus, Type 2AdolescentAdultChildHumansObesityOverweightAnti-Obesity Agentsanti-obesity pharmacotherapyGLP-1 RAobesitypediatricsphentermine/topiramate combinationtype 2 diabetes (T2D)

Identifiers

PMID36387846
PMCPMC9647073
OpenAlexW4307631040

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.