Evidence map›Paper›PMID 36388796›Full record

ArticleAnnals of translational medicine2022

Investigation of the hemostatic mechanism of

Yinghao Zheng, Yun Wang, Mengyu Xia, Yanan Song, Ya Gao, Lan Zhang, Cun Zhang

Open access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. The Prediction of Antioxidant Q-Markers forMolecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Yinghao Zheng *Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Yun Wang *Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Mengyu XiaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Yanan SongInstitute of Pharmacology, Shandong First Medical University, Taian, China.
Ya GaoInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Lan ZhangCollege of Traditional Chinese medicine, Yunnan University of Chinese Medicine, Kunming, China.
Cun ZhangInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNAnhui University of Traditional Chinese Medicine · CNShandong First Medical University · CNTaishan Medical University · CNYunnan University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: As documented in the Chinese Pharmacopoeia, Methods: Using ultra-performance liquid chromatography (UPLC) analysis, we quantified the main active ingredients for a preliminary quality assessment of GFP. The pharmacology study was conducted to confirm the essential antihemorrhagic effects of GFP. A rat model of ethanol-induced gastric hemorrhage was established and was followed by intervention with GFP in low, middle, and high doses (4.5, 9, 18 g/kg). Gastric tissues were harvested for macroscopic and histological evaluation of lesions. The contents of thromboxane B2 (TXB Results: The study found ten main active ingredients that could be used for quality control of GFP. Importantly, the middle and high doses of GFP were found to promote the healing of gastric bleeding. The content of 6-keto-PGF Conclusions: GFP exhibits a promising effect in ameliorating bleeding, with the relevant molecular mechanisms possibly being related to the regulation of the immune system and platelet activation. Therefore, GFP can potentially exert a protective effect on gastrointestinal bleeding in clinic.

Indexed as

Gardeniae fructus Praeparatus (GFP)hemostasisnetwork pharmacology

Identifiers

PMID36388796
PMCPMC9652550
OpenAlexW4307709176

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.