Evidence map›Paper›PMID 36389793›Full record

ArticleFrontiers in immunology2022

The magnitude of the germinal center B cell and T follicular helper cell response predicts long-lasting antibody titers to plague vaccination.

Darrell R Galloway, Nguyen X Nguyen, Jiahui Li, Nicholas Houston, Gage Gregersen, E Diane Williamson, Frank W Falkenberg, James N Herron, J Scott Hale

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. An adenoviral-vectored vaccine protects mice against aerosol challenge with Yersinia pestis.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Darrell R GallowayDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, United States.
Nguyen X NguyenDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT, United States.
Jiahui LiDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, United States.
Nicholas HoustonDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, United States.
Gage GregersenDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, United States.
E Diane WilliamsonChemical Biological Radiological Division, Defense Science and Technology Laboratory (DSTL) Porton Down, Salisbury, United Kingdom.
Frank W FalkenbergCyTuVax B.V., Maastricht, Netherlands.
James N HerronDepartment of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, United States.
J Scott HaleDepartment of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City, UT, United States.
University of Utah · USDefence Science and Technology Laboratory · GB

Funding

Epigenetic programming of T follicular helper cell differentiationR01AI137238 · NIAID · UNIVERSITY OF UTAH · PI HALE, JEFFREY SCOTT · 2018 to 2022
$2.9M
NIAID NIH HHS R01 AI137238
6 · The paper itself

Abstract

The development of a safe and effective vaccine against

Indexed as

Aluminum HydroxideGerminal CenterAdjuvants, ImmunologicAnimalsImmunization, SecondaryMiceT Follicular Helper CellsVaccinationVaccines, SubunitVaccines, SyntheticAdjuvants, ImmunologicAluminum HydroxideVaccines, SubunitVaccines, SyntheticantibodiesB cell responsegerminal centerimmunological memory and vaccinessubunit vaccineT follicular helper cellvaccinationYersinia pestis (plague)

Identifiers

PMID36389793
PMCPMC9650111
OpenAlexW4307706622

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.