Evidence mapPaperPMID 36398992Full record

ArticleDiabetic medicine : a journal of the British Diabetic Association2023

Producing a preference-based quality of LIFE measure to quantify the impact of HYPOGLYCAEMIA on people living with diabetes: A mixed-methods research protocol.

Jill Carlton, Philip Powell, Donna Rowen, Melanie Broadley, Frans Pouwer, Jane Speight, Simon Heller, Mari-Anne Gall, Myriam Rosilio, Christopher J Child and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Diabetic medicine : a journal of the British Diabetic Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. 'There is more to life than HbADiabetic medicine : a journal of the British Diabetic Association · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 4 countries.

Jill CarltonSchool of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.ORCID 0000-0002-9373-7663
Philip PowellSchool of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.ORCID 0000-0003-1169-3431
Donna RowenSchool of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.ORCID 0000-0003-3018-5109
Melanie BroadleyDepartment of Psychology, University of Southern Denmark, Odense, Denmark.ORCID 0000-0003-4408-6304
Frans PouwerDepartment of Psychology, University of Southern Denmark, Odense, Denmark.ORCID 0000-0002-8172-9818
Jane SpeightDepartment of Psychology, University of Southern Denmark, Odense, Denmark.ORCID 0000-0002-1204-6896
Simon HellerDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, UK.ORCID 0000-0002-2425-9565
Mari-Anne GallNovo Nordisk A/S, Medical & Science, Insulin & Devices, Clinical Drug Development, Søborg, Denmark.ORCID 0000-0001-7149-0092
Myriam RosilioEli Lilly & Company, Diabetes Medical Unit, Neuilly sur seine, France.ORCID 0000-0003-0296-9061
Christopher J ChildEli Lilly and Company, Insulins Development Team, Bracknell, UK.ORCID 0000-0002-6195-2780
Jonathan CominsNovo Nordisk A/S, Medical & Science, Centre of Expertise, Patient Focused Drug Development, Søborg, Denmark.ORCID 0000-0002-8284-114X
Rory J McCrimmonSystems Medicine, School of Medicine, University of Dundee, Dundee, Scotland.ORCID 0000-0002-3957-1981
Bastiaan de GalanDepartment of Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands.ORCID 0000-0002-1255-7741
John BrazierSchool of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.ORCID 0000-0001-8645-4780
Hypo-RESOLVE CONSORTIUM
University of Sheffield · GBNovo Nordisk (Denmark) · DKDeakin University · AUEli Lilly (United Kingdom) · GBRadboud University Nijmegen · NLSteno Diabetes Centers · DKUniversity of Dundee · GBUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAssessment of patient-reported outcome measures (PROMs), including quality of life (QoL), is essential in diabetes research and care. However, a recent review concluded that current hypoglycaemia-specific PROMs have limited evidence of validity, reliability and responsiveness for assessing the impact of hypoglycaemia on QoL in people living with diabetes. None of the PROMs identified could be used directly to inform the cost-effectiveness of treatments and interventions. There is a need for a new hypoglycaemia-specific QoL PROM, which can be used directly to inform economic evaluations.

aimsThis project has three aims: (a) To develop draft PROM content for measuring the impact of hypoglycaemia on QoL in adults with diabetes. (b) To refine the draft content using cognitive debriefing interviews and psychometrics. This will result in a condition-specific PROM that can be used to quantify the impact of hypoglycaemia upon QoL. (c) To generate a preference-based measure (PBM) that will enable utility values to be calculated for economic evaluation.

methodsA mixed-methods, three-stage design is used: (a) Qualitative interviews will inform the draft PROM content. (b) Cognitive debriefing interview data will be used to refine the draft PROM content. The PROM will be administered in a large-scale survey to enable psychometric validation. Final item selection for the PROM will be informed by psychometric performance, translatability assessment and input from stakeholder groups. (c) A classification system will be generated, comprising a reduced number of items from the PROM. A valuation survey will be conducted to derive a value set for the PBM.

Indexed as

Diabetes MellitusHypoglycemiaAdultHumansPsychometricsQuality of LifeReproducibility of ResultsResearch DesignSurveys and Questionnairesdiabeteshypoglycaemiapatient-reported outcome measurespreference-based measurepsychometricsqualitative researchquality of life

Identifiers

PMID36398992
PMCPMC10099528
OpenAlexW4309293693

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.