Evidence map›Paper›PMID 36400364›Full record

Observational studyJournal of vascular surgery2023

Incidence and predictors of acute limb ischemia in acute myocardial infarction complicated by cardiogenic shock.

Carlos M Romero, Irfan Shafi, Aadhar Patil, Eric Secemsky, Ido Weinburg, Raghu Kolluri, Huaqing Zhao, Vladimir Lakther, Riyaz Bashir

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of vascular surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Carlos M RomeroDepartment of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Irfan ShafiDivision of Cardiovascular Medicine, Wayne State University/DMC, Detroit, MI.
Aadhar PatilDivision of Cardiovascular Disease, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Eric SecemskyDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Ido WeinburgVASCORE, Massachusetts General Hospital, Boston, MA.
Raghu KolluriVascular Medicine & Vascular Labs, OhioHealth, Columbus, OH.
Huaqing ZhaoDepartment of Biomedical Education and Data Science, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Vladimir LaktherDivision of Cardiovascular Disease, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
Riyaz BashirDivision of Cardiovascular Disease, Lewis Katz School of Medicine at Temple University, Philadelphia, PA. Electronic address: riyaz.bashir@tuhs.temple.edu.
Temple University · USBeth Israel Deaconess Medical Center · USMassachusetts General Hospital · USOhioHealth · USWayne State University · US

Funding

Shared Decision-Making to Improve the Health Status of Patients with Claudication: Developing and Implementing Strategies to Individualize Treatment DecisionsK23HL150290 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SECEMSKY, ERIC ALEXANDER · 2020 to 2024
$851k
NHLBI NIH HHS K23 HL150290
6 · The paper itself

Abstract

objectiveTo describe the incidence and predictors of acute limb ischemia (ALI) in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS).

methodsPatients with index hospitalizations for AMI complicated by cardiogenic shock from 2016 to 2019 in the US National Readmission Database were identified. We evaluated the incidence of ALI and its associated mortality, length of stay, and cost of hospitalization. We used multivariable logistic regression to determine independent predictors of ALI in this population.

resultsA total of 84,615 patients had AMI complicated by cardiogenic shock and 1302 (1.54%) developed ALI. The rates of ALI increased from 1.29% in 2016 to 1.66% in 2019 (P ≤ .002). The use of microaxial mechanical circulatory support increased from 2.25% in 2016 to 13.36% in 2019 (P = .0001). The major predictors of ALI included peripheral arterial disease (odds ratio [OR], 7.34; 95% confidence interval [CI], 6.12-8.81), venoarterial extracorporeal membrane oxygenation (OR, 4.40; 95% CI, 3.19-6.07), and microaxial mechanical circulatory support (OR, 3.12; 95% CI, 2.74-3.55). ALI in patients with cardiogenic shock was associated higher mortality (39.20% vs 33.53%; P ≤ .0001).

conclusionsThis nationwide observational study shows that ALI is an important complication of AMI with cardiogenic shock. This complication is associated with higher mortality. In addition to peripheral artery disease, the use of mechanical circulatory devices was associated with significantly higher rates of ALI.

Indexed as

Heart-Assist DevicesMyocardial InfarctionPeripheral Arterial DiseaseHospital MortalityHumansIncidenceRetrospective StudiesShock, CardiogenicTreatment OutcomeAmputationMechanical circulatory support (MCS)Peripheral artery disease (PAD)Venoarterial extracorporeal membrane oxygenation (VA-ECMO)

Identifiers

PMID36400364
PMCPMC12697302
OpenAlexW4309335775

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.