Evidence map›Paper›PMID 36402801›Full record

ArticleScientific reports2022

High speed photo-mediated ultrasound therapy integrated with OCTA.

Yan Li, Yuchen Song, Runze Li, Wangcun Jia, Fengyi Zhang, Xiaoming Hu, Lidek Chou, Qifa Zhou, Zhongping Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Photo-Mediated Ultrasound Therapy (PUT) for the Treatment of Deep Cutaneous Vasculature.IEEE open journal of ultrasonics, ferroelectrics, and frequency control · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. A review on photo-mediated ultrasound therapy.Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yan LiBeckman Laser Institute, University of California, Irvine, Irvine, CA, 92612, USA.
Yuchen SongBeckman Laser Institute, University of California, Irvine, Irvine, CA, 92612, USA.
Runze LiDepartment of Ophthalmology and Biomedical Engineering, University of Southern California, Los Angeles, CA, 90089, USA.
Wangcun JiaBeckman Laser Institute, University of California, Irvine, Irvine, CA, 92612, USA.
Fengyi ZhangBeckman Laser Institute, University of California, Irvine, Irvine, CA, 92612, USA.
Xiaoming HuBeckman Laser Institute, University of California, Irvine, Irvine, CA, 92612, USA.
Lidek ChouBeckman Laser Institute, University of California, Irvine, Irvine, CA, 92612, USA.
Qifa ZhouDepartment of Ophthalmology and Biomedical Engineering, University of Southern California, Los Angeles, CA, 90089, USA.
Zhongping ChenBeckman Laser Institute, University of California, Irvine, Irvine, CA, 92612, USA. z2chen@uci.edu.
University of California, Irvine · USBeckman Laser Institute and Medical Clinic · USUniversity of Southern California · US

Funding

Phase resolved ARF optical coherence elastography for intravascular imagingR01HL125084 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, ZHOU, QIFA · 2014 to 2023
$5.6M
Combined OCT/US/PAT system for intravascular ImagingR01HL127271 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, PATEL, PRANAV · 2015 to 2018
$2.7M
High-resolution Elastographic Assessment of the Optic Nerve HeadR01EY028662 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, SIGAL, IAN A · 2018 to 2021
$2.7M
In vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging TechnologyR01EB030024 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, WONG, BRIAN · 2020 to 2024
$2.3M
Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA EndoscopyR01EB030558 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, LANE, FELICIA LUCIA · 2021 to 2021
$1.9M
NEI NIH HHS R01 EY028662NHLBI NIH HHS R01 HL125084NHLBI NIH HHS R01 HL127271NIBIB NIH HHS R01 EB030024NIBIB NIH HHS R01 EB030558
6 · The paper itself

Abstract

Photo-mediated Ultrasound Therapy (PUT), as a new anti-vascular technique, can promote cavitation activity to selectively destruct blood vessels with a significantly lower amount of energy when compared to energy level required by other laser and ultrasound treatment therapies individually. Here, we report the development of a high speed PUT system based on a 50-kHz pulsed laser to achieve faster treatment, decreasing the treatment time by a factor of 20. Furthermore, we integrated it with optical coherence tomography angiography (OCTA) for real time monitoring. The feasibility of the proposed OCTA-guided PUT was validated through in vivo rabbit experiments. The addition of OCTA to PUT allows for quantitative prescreening and real time monitoring of treatment response, thereby enabling implementation of individualized treatment strategies.

Indexed as

Tomography, Optical CoherenceUltrasonic TherapyAnimalsFluorescein AngiographyLasersRabbits

Identifiers

PMID36402801
PMCPMC9675827
OpenAlexW4309563837

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.