The roles of MTHFR (C677T, A1298C) and MGP (G-7A, T-138C) gene variations in development of diabetic nephropathy in patients with type 2 diabetes mellitus.

Arzu Ay, Nevra Alkanli, Idris Kurt, Sedat Ustundag, Tammam Sipahi, Necdet Sut

Open access · greenAbstract read

In one paragraph

Article in Journal of diabetes and metabolic disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed, 1 pooled it

0.9field-weighted citation impact, top 27% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

Association betweenFrontiers in endocrinology · 2023
Pooled it

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Arzu AyDepartment of Biophysics, Faculty of Medicine, Trakya University, Edirne, Turkey.ORCID 0000-0002-8412-091X

Nevra AlkanliDepartment of Biophysics, Faculty of Medicine, Haliç University, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-3745-8838

Idris KurtDepartment of Internal Medicine (Gastroenterology), Faculty of Medicine, Trakya University, Edirne, Turkey.ORCID 0000-0001-5966-1055

Sedat UstundagDepartment of Internal Medicine (Nephrology), Faculty of Medicine, Trakya University, Edirne, Turkey.ORCID 0000-0002-8502-9181

Tammam SipahiDepartment of Biophysics, Faculty of Medicine, Trakya University, Edirne, Turkey.ORCID 0000-0003-1057-9864

Necdet SutDepartment of Biostatistics and Medical Informatics, Faculty of Medicine, Trakya University, Edirne, Turkey.ORCID 0000-0001-6678-482X

Trakya University · TRHaliç University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The goal of this study is to determine the role of MTHFR (C677T, A1298C) and MGP (G-7A, T-138C) gene variations in DN development. Methods: There were 61 DN patients and 55 healthy controls in this study. The genotype distributions of these gene variations were determined using PCR and RFLP methods. Results: According to our study, there was no significant relationship between these gene variations and DN ( Conclusion: In our study, although MTHFR and MGP gene variations were not risk factors, the GA-TT combined genotype of the MGP (G-7A/T-138C) gene variation was detected as an important risk factor for DN.

Indexed as

A1298C) gene variationsDiabetic nephropathyMGP (G-7AMTHFR (C677TPCRRFLPT-138C) gene variations

Identifiers

PMID36404848

DOI10.1007/s40200-022-01061-9

PMCPMC9672197

OpenAlexW4281629897

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.