Evidence map›Paper›PMID 36405682›Full record

ArticleFrontiers in immunology2022

Primary antibody response after influenza virus infection is first dominated by low-mutated HA-stem antibodies followed by higher-mutated HA-head antibodies.

Aafke Aartse, Daniella Mortier, Petra Mooij, Sam Hofman, Marlies M van Haaren, Martin Corcoran, Gunilla B Karlsson Hedestam, Dirk Eggink, Mathieu Claireaux, Willy M J M Bogers and 2 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aafke AartseDepartment of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.
Daniella MortierDepartment of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.
Petra MooijDepartment of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.
Sam HofmanDepartment of Parasitology, Biomedical Primate Research Centre, Rijswijk, Netherlands.
Marlies M van HaarenLaboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, University of Amsterdam, Amsterdam, Netherlands.
Martin CorcoranDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet (KI), Stockholm, Sweden.
Gunilla B Karlsson HedestamDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet (KI), Stockholm, Sweden.
Dirk EgginkLaboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, University of Amsterdam, Amsterdam, Netherlands.
Mathieu ClaireauxLaboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, University of Amsterdam, Amsterdam, Netherlands.
Willy M J M BogersDepartment of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.
Marit J van GilsLaboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, University of Amsterdam, Amsterdam, Netherlands.
Gerrit KoopmanDepartment of Virology, Biomedical Primate Research Centre, Rijswijk, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies have shown that the first encounter with influenza virus shapes the immune response to future infections or vaccinations. However, a detailed analysis of the primary antibody response is lacking as this is difficult to study in humans. It is therefore not known what the frequency and dynamics of the strain-specific hemagglutinin (HA) head- and stem-directed antibody responses are directly after primary influenza virus infection. Here, sera of twelve H1N1

Indexed as

Influenza A Virus, H1N1 SubtypeInfluenza, HumanOrthomyxoviridae InfectionsAnimalsAntibodies, ViralAntibody FormationHemagglutinin Glycoproteins, Influenza VirusHemagglutininsHumansAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusHemagglutininsantibody responseHA-headHA-stemhemagglutinininfluenza A virusprimary response

Identifiers

PMID36405682
PMCPMC9670313

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.