ReviewClinical autonomic research : official journal of the Clinical Autonomic Research Society2022
Brain and cardiovascular-related changes are associated with aging, hypertension, and atrial fibrillation.
Review in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Machine Learning-Derived Cardiovascular Aging Phenotypes From Cardiac Function and Stroke Risk in the UK Biobank: Cohort Study.JMIR aging · 2026Article
- Exploring the bidirectional relationships between MRI resting-state functional connectivity networks and cardiovascular diseases: a Mendelian randomization study.Brain informatics · 2025Article
- Lifetime Deletion of Skeletal Muscle Keap1 Attenuates Aging-Induced Cardiac Dysfunction via an Nrf2-Antioxidant Mechanism.Antioxidants (Basel, Switzerland) · 2025Article
- The association between enlarged perivascular spaces and muscle sympathetic nerve activity in normotensive and hypertensive humans.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- The Physiological Component of the BOLD Signal: Impact of Age and Heart Rate Variability Biofeedback Training.bioRxiv : the preprint server for biology · 2025Article
- Causal associations between hypertension and abnormal brain cortical structures: Insights from a bidirectional Mendelian randomization study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- The physiological component of the BOLD signal: Impact of age and heart rate variability biofeedback training.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Bidirectional Crosstalk between the Heart and Brain in Alzheimer's Disease.Aging and disease · 2024Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe neural pathways in which the brain regulates the cardiovascular system is via sympathetic and parasympathetic control of the heart and sympathetic control of the systemic vasculature. Various cortical and sub-cortical sites are involved, but how these critical brain regions for cardiovascular control are altered in healthy aging and other risk conditions that may contribute to cardiovascular disease is uncertain.
methodsHere we review the functional and structural brain changes in healthy aging, hypertension, and atrial fibrillation - noting their potential influence on the autonomic nervous system and hence on cardiovascular control.
resultsEvidence suggests that aging, hypertension, and atrial fibrillation are each associated with functional and structural changes in specific areas of the central nervous system involved in autonomic control. Increased muscle sympathetic nerve activity (MSNA) and significant alterations in the brain regions involved in the default mode network are commonly reported in aging, hypertension, and atrial fibrillation.
conclusionsFurther studies using functional and structural magnetic resonance imaging (MRI) coupled with autonomic nerve activity in healthy aging, hypertension, and atrial fibrillation promise to reveal the underlying brain circuitry modulating the abnormal sympathetic nerve activity in these conditions. This understanding will guide future therapies to rectify dysregulation of autonomic and cardiovascular control by the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.